Looking to buy FOX-04 for laboratory senescence research? FOX-04, short for FOXO4 D-Retro-Inverso, is a synthetic research peptide designed to interfere with the interaction between the FOXO4 transcription factor and the p53 tumour-suppressor protein.<\/p>\n
This protein interaction has been investigated for its role in supporting the survival of certain senescent cells. Senescent cells have permanently stopped dividing but may remain metabolically active and release signalling molecules associated with tissue ageing and inflammatory processes.<\/p>\n
In a landmark 2017 preclinical study led by researchers affiliated with Erasmus University Medical Center Rotterdam, FOXO4-DRI preferentially reduced the viability of senescent cells by disrupting FOXO4\u2013p53 binding. This promoted the relocation of active p53 and initiated apoptosis in the senescent cells studied. Control cells were less affected under the specific experimental conditions used.<\/p>\n
Peptides Divas supplies FOXO4-DRI in a 10 mg format as a stable lyophilised powder. Each batch is accompanied by batch-specific analytical documentation.<\/p>\n
Tento produkt je ur\u010den v\u00fdhradn\u011b pro laboratorn\u00ed v\u00fdzkumn\u00e9 \u00fa\u010dely. Nen\u00ed ur\u010den pro hum\u00e1nn\u00ed ani veterin\u00e1rn\u00ed pou\u017eit\u00ed.<\/strong><\/p>\n FOXO4-DRI is studied as an experimental senolytic peptide. In preclinical cell models, it has been shown to compete with FOXO4 for p53 binding, promoting p53 relocation from the nucleus and activating apoptosis-associated pathways in certain senescent cells.<\/p>\n These findings are model-dependent and should not be interpreted as evidence that FOXO4-DRI targets every type of senescent cell.<\/p>\n FOXO4 je transkrip\u010dn\u00ed faktor zapojen\u00fd do bun\u011b\u010dn\u00fdch stresov\u00fdch reakc\u00ed, homeost\u00e1zy a regulace bun\u011b\u010dn\u00e9ho osudu. Ve zkouman\u00fdch modelech st\u00e1rnouc\u00edch bun\u011bk pomohl FOXO4 udr\u017eet p53 v j\u00e1d\u0159e. FOXO4-DRI byl navr\u017een tak, aby tuto interakci naru\u0161oval a uvol\u0148oval p53 z t\u011bchto jadern\u00fdch komplex\u016f.<\/p>\n V my\u0161\u00edch modelech bylo experiment\u00e1ln\u00ed pod\u00e1v\u00e1n\u00ed FOXO4-DRI spojeno se zlep\u0161en\u00edm vybran\u00fdch ukazatel\u016f tk\u00e1\u0148ov\u00e9 homeost\u00e1zy, v\u010detn\u011b marker\u016f souvisej\u00edc\u00edch s funkc\u00ed ledvin, hustotou srsti a fyzickou aktivitou. Tyto v\u00fdsledky byly z\u00edsk\u00e1ny u zv\u00ed\u0159at a nelze je p\u0159\u00edmo extrapolovat na \u010dlov\u011bka.<\/p>\n FOXO4-DRI uses a D-retro-inverso design in which D-amino acids are arranged in reverse sequence order. This design is commonly investigated as a method of preserving functional side-chain orientation while increasing resistance to proteolytic degradation compared with corresponding conventional L-peptides.<\/p>\n The exact stability and performance of an individual batch depend on its composition, handling and experimental conditions.<\/p>\n Some senescent cells produce a collection of inflammatory cytokines, growth factors and proteases known as the senescence-associated secretory phenotype, or SASP.<\/p>\n By investigating the selective removal of senescent cells, researchers may study whether FOXO4-DRI influences SASP-related signalling and inflammatory processes in controlled experimental models. This remains a preclinical research field and is not an established clinical application.<\/p>\n Ke ka\u017ed\u00e9 \u0161ar\u017ei FOXO4-DRI je dod\u00e1v\u00e1n certifik\u00e1t o anal\u00fdze. V z\u00e1vislosti na dostupn\u00e9 dokumentaci \u0161ar\u017ee mohou analytick\u00e9 testy zahrnovat:<\/p>\n P\u0159esn\u00e9 specifikace a analytick\u00e9 v\u00fdsledky dodan\u00e9 \u0161ar\u017ee naleznete v\u017edy v certifik\u00e1tu anal\u00fdzy.<\/p>\n FOXO4-DRI 10 mg je dod\u00e1v\u00e1n v\u00fdhradn\u011b pro kontrolovan\u00fd v\u011bdeck\u00fd a laboratorn\u00ed v\u00fdzkum. Nejedn\u00e1 se o l\u00e9\u010div\u00fd p\u0159\u00edpravek, dopln\u011bk stravy ani kosmetick\u00fd p\u0159\u00edpravek a nen\u00ed schv\u00e1len pro lidskou spot\u0159ebu, terapeutick\u00e9 aplikace, klinick\u00e9 ani veterin\u00e1rn\u00ed pou\u017eit\u00ed.<\/p>","protected":false},"excerpt":{"rendered":" Looking to buy FOXO4-DRI for laboratory senescence research? FOXO4-DRI, short for FOXO4 D-Retro-Inverso, is a synthetic research peptide designed to interfere with the interaction between the FOXO4 transcription factor and the p53 tumour-suppressor protein.<\/p>\n This protein interaction has been investigated for its role in supporting the survival of certain senescent cells. Senescent cells have permanently stopped dividing but may remain metabolically active and release signalling molecules associated with tissue ageing and inflammatory processes.<\/p>\n In a landmark 2017 preclinical study led by researchers affiliated with Erasmus University Medical Center Rotterdam, FOXO4-DRI preferentially reduced the viability of senescent cells by disrupting FOXO4\u2013p53 binding. This promoted the relocation of active p53 and initiated apoptosis in the senescent cells studied. Control cells were less affected under the specific experimental conditions used.<\/p>\n Peptides Divas supplies FOXO4-DRI in a 10 mg format as a stable lyophilised powder. Each batch is accompanied by batch-specific analytical documentation.<\/p>\n Tento produkt je ur\u010den v\u00fdhradn\u011b pro laboratorn\u00ed v\u00fdzkumn\u00e9 \u00fa\u010dely. Nen\u00ed ur\u010den pro hum\u00e1nn\u00ed ani veterin\u00e1rn\u00ed pou\u017eit\u00ed.<\/strong><\/p>","protected":false},"featured_media":741,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false,"nf_dc_page":"","om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"product_brand":[],"product_cat":[34],"product_tag":[46],"class_list":["post-740","product","type-product","status-publish","has-post-thumbnail","product_cat-recovery-repair","product_tag-10-mg","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"\nSpecifikace produktu FOXO4-DRI<\/h2>\n
\n\n
\n \nSpecifikace<\/th>\n Podrobnosti<\/th>\n<\/tr>\n<\/thead>\n \n N\u00e1zev produktu<\/td>\n FOXO4-DRI<\/td>\n<\/tr>\n \n Cel\u00e9 jm\u00e9no<\/td>\n FOXO4 D-Retro-Inverso peptid<\/td>\n<\/tr>\n \n Mno\u017estv\u00ed<\/td>\n 10 mg na lahvi\u010dku<\/td>\n<\/tr>\n \n Kategorie v\u00fdzkumu<\/td>\n Bun\u011b\u010dn\u00e1 senescence a senolytick\u00fd v\u00fdzkum<\/td>\n<\/tr>\n \n Zkouman\u00fd mechanismus<\/td>\n Naru\u0161en\u00ed interakce protein\u016f FOXO4\u2013p53<\/td>\n<\/tr>\n \n \u010cistota<\/td>\n \u226599,5% pomoc\u00ed HPLC<\/td>\n<\/tr>\n \n Formul\u00e1\u0159<\/td>\n Lyofilizovan\u00fd pr\u00e1\u0161ek<\/td>\n<\/tr>\n \n Peptidov\u00fd design<\/td>\n D-retro-inverzn\u00ed struktura<\/td>\n<\/tr>\n \n Skladov\u00e1n\u00ed<\/td>\n Skladujte p\u0159i teplot\u011b -20 \u00b0C, chra\u0148te p\u0159ed sv\u011btlem a vlhkost\u00ed<\/td>\n<\/tr>\n \n Dokumentace<\/td>\n Certifik\u00e1t anal\u00fdzy specifick\u00fd pro danou \u0161ar\u017ei<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Relevance v\u011bdeck\u00e9ho v\u00fdzkumu<\/h2>\n
V\u00fdzkum senescentn\u00edch bun\u011bk<\/h3>\n
Interakce FOXO4\u2013p53<\/h3>\n
V\u00fdzkum biologie st\u00e1rnut\u00ed<\/h3>\n
D-Retro-Inverso Peptidov\u00fd design<\/h3>\n
SASP a v\u00fdzkum z\u00e1n\u011bt\u016f<\/h3>\n
Zaji\u0161t\u011bn\u00ed kvality<\/h2>\n
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Pouze pro v\u00fdzkumn\u00e9 \u00fa\u010dely<\/h2>\n
FOXO4-DRI 10 mg \u2013 Senolytic Research Peptide<\/h1>\n