Looking to buy FOX-04 for laboratory senescence research? FOX-04, short for FOXO4 D-Retro-Inverso, is a synthetic research peptide designed to interfere with the interaction between the FOXO4 transcription factor and the p53 tumour-suppressor protein.<\/p>\n
This protein interaction has been investigated for its role in supporting the survival of certain senescent cells. Senescent cells have permanently stopped dividing but may remain metabolically active and release signalling molecules associated with tissue ageing and inflammatory processes.<\/p>\n
In a landmark 2017 preclinical study led by researchers affiliated with Erasmus University Medical Center Rotterdam, FOXO4-DRI preferentially reduced the viability of senescent cells by disrupting FOXO4\u2013p53 binding. This promoted the relocation of active p53 and initiated apoptosis in the senescent cells studied. Control cells were less affected under the specific experimental conditions used.<\/p>\n
Peptides Divas supplies FOXO4-DRI in a 10 mg format as a stable lyophilised powder. Each batch is accompanied by batch-specific analytical documentation.<\/p>\n
Dieses Produkt ist ausschlie\u00dflich f\u00fcr Forschungszwecke im Labor bestimmt. Es ist nicht f\u00fcr die Anwendung am Menschen oder am Tier vorgesehen.<\/strong><\/p>\n FOXO4-DRI is studied as an experimental senolytic peptide. In preclinical cell models, it has been shown to compete with FOXO4 for p53 binding, promoting p53 relocation from the nucleus and activating apoptosis-associated pathways in certain senescent cells.<\/p>\n These findings are model-dependent and should not be interpreted as evidence that FOXO4-DRI targets every type of senescent cell.<\/p>\n FOXO4 ist ein Transkriptionsfaktor, der an zellul\u00e4ren Stressreaktionen, der Hom\u00f6ostase und der Zelldifferenzierung beteiligt ist. In den untersuchten Modellen seneszenter Zellen trug FOXO4 dazu bei, p53 im Zellkern zu halten. FOXO4-DRI wurde entwickelt, um diese Interaktion zu unterbrechen und p53 aus diesen Kernkomplexen freizusetzen.<\/p>\n In Mausmodellen ging die experimentelle Verabreichung von FOXO4-DRI mit Verbesserungen ausgew\u00e4hlter Parameter der Gewebehom\u00f6ostase einher, darunter Marker der Nierenfunktion, der Felldichte und der k\u00f6rperlichen Aktivit\u00e4t. Diese Ergebnisse wurden an Tieren erzielt und lassen sich nicht direkt auf den Menschen \u00fcbertragen.<\/p>\n FOXO4-DRI uses a D-retro-inverso design in which D-amino acids are arranged in reverse sequence order. This design is commonly investigated as a method of preserving functional side-chain orientation while increasing resistance to proteolytic degradation compared with corresponding conventional L-peptides.<\/p>\n The exact stability and performance of an individual batch depend on its composition, handling and experimental conditions.<\/p>\n Some senescent cells produce a collection of inflammatory cytokines, growth factors and proteases known as the senescence-associated secretory phenotype, or SASP.<\/p>\n By investigating the selective removal of senescent cells, researchers may study whether FOXO4-DRI influences SASP-related signalling and inflammatory processes in controlled experimental models. This remains a preclinical research field and is not an established clinical application.<\/p>\n Jede FOXO4-DRI-Charge wird mit einem Analysezertifikat geliefert. Je nach verf\u00fcgbarer Chargendokumentation k\u00f6nnen die analytischen Pr\u00fcfungen Folgendes umfassen:<\/p>\n Bitte konsultieren Sie stets das Analysezertifikat, um die genauen Spezifikationen und Analyseergebnisse der gelieferten Charge zu erfahren.<\/p>\n FOXO4-DRI 10 mg wird ausschlie\u00dflich f\u00fcr kontrollierte wissenschaftliche und Laborforschung geliefert. Es handelt sich nicht um ein Arzneimittel, Nahrungserg\u00e4nzungsmittel oder Kosmetikprodukt und es ist nicht f\u00fcr den menschlichen Verzehr, therapeutische Anwendungen, klinische oder veterin\u00e4rmedizinische Zwecke zugelassen.<\/p>","protected":false},"excerpt":{"rendered":" Looking to buy FOXO4-DRI for laboratory senescence research? FOXO4-DRI, short for FOXO4 D-Retro-Inverso, is a synthetic research peptide designed to interfere with the interaction between the FOXO4 transcription factor and the p53 tumour-suppressor protein.<\/p>\n This protein interaction has been investigated for its role in supporting the survival of certain senescent cells. Senescent cells have permanently stopped dividing but may remain metabolically active and release signalling molecules associated with tissue ageing and inflammatory processes.<\/p>\n In a landmark 2017 preclinical study led by researchers affiliated with Erasmus University Medical Center Rotterdam, FOXO4-DRI preferentially reduced the viability of senescent cells by disrupting FOXO4\u2013p53 binding. This promoted the relocation of active p53 and initiated apoptosis in the senescent cells studied. Control cells were less affected under the specific experimental conditions used.<\/p>\n Peptides Divas supplies FOXO4-DRI in a 10 mg format as a stable lyophilised powder. Each batch is accompanied by batch-specific analytical documentation.<\/p>\n Dieses Produkt ist ausschlie\u00dflich f\u00fcr Forschungszwecke im Labor bestimmt. Es ist nicht f\u00fcr die Anwendung am Menschen oder am Tier vorgesehen.<\/strong><\/p>","protected":false},"featured_media":741,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false,"nf_dc_page":"","om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"product_brand":[],"product_cat":[34],"product_tag":[46],"class_list":["post-740","product","type-product","status-publish","has-post-thumbnail","product_cat-recovery-repair","product_tag-10-mg","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"\nFOXO4-DRI Produktspezifikationen<\/h2>\n
\n\n
\n \nSpezifikation<\/th>\n Details<\/th>\n<\/tr>\n<\/thead>\n \n Produktname<\/td>\n FOXO4-DRI<\/td>\n<\/tr>\n \n Vollst\u00e4ndiger Name<\/td>\n FOXO4 D-Retro-Inverso-Peptid<\/td>\n<\/tr>\n \n Menge<\/td>\n 10 mg pro Durchstechflasche<\/td>\n<\/tr>\n \n Forschungskategorie<\/td>\n Zellul\u00e4re Seneszenz und senolytische Forschung<\/td>\n<\/tr>\n \n Untersuchter Mechanismus<\/td>\n St\u00f6rung der FOXO4\u2013p53-Protein-Interaktion<\/td>\n<\/tr>\n \n Reinheit<\/td>\n \u226599,51 TP3T mittels HPLC<\/td>\n<\/tr>\n \n Bilden<\/td>\n Lyophilisiertes Pulver<\/td>\n<\/tr>\n \n Peptiddesign<\/td>\n D-Retro-Inverso-Struktur<\/td>\n<\/tr>\n \n Lagerung<\/td>\n Bei \u221220 \u00b0C lagern, vor Licht und Feuchtigkeit sch\u00fctzen.<\/td>\n<\/tr>\n \n Dokumentation<\/td>\n Chargenspezifisches Analysezertifikat<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Relevanz f\u00fcr die wissenschaftliche Forschung<\/h2>\n
Forschung zu alternden Zellen<\/h3>\n
FOXO4\u2013p53-Interaktion<\/h3>\n
Alternsbiologieforschung<\/h3>\n
D-Retro-Inverso-Peptid-Design<\/h3>\n
SASP und Entz\u00fcndungsforschung<\/h3>\n
Qualit\u00e4tssicherung<\/h2>\n
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Nur f\u00fcr Forschungszwecke<\/h2>\n
FOXO4-DRI 10 mg \u2013 Senolytic Research Peptide<\/h1>\n