Looking to buy FOX-04 for laboratory senescence research? FOX-04, short for FOXO4 D-Retro-Inverso, is a synthetic research peptide designed to interfere with the interaction between the FOXO4 transcription factor and the p53 tumour-suppressor protein.<\/p>\n
This protein interaction has been investigated for its role in supporting the survival of certain senescent cells. Senescent cells have permanently stopped dividing but may remain metabolically active and release signalling molecules associated with tissue ageing and inflammatory processes.<\/p>\n
In a landmark 2017 preclinical study led by researchers affiliated with Erasmus University Medical Center Rotterdam, FOXO4-DRI preferentially reduced the viability of senescent cells by disrupting FOXO4\u2013p53 binding. This promoted the relocation of active p53 and initiated apoptosis in the senescent cells studied. Control cells were less affected under the specific experimental conditions used.<\/p>\n
Peptides Divas supplies FOXO4-DRI in a 10 mg format as a stable lyophilised powder. Each batch is accompanied by batch-specific analytical documentation.<\/p>\n
Este producto est\u00e1 destinado exclusivamente a fines de investigaci\u00f3n de laboratorio. No est\u00e1 destinado para uso humano ni veterinario.<\/strong><\/p>\n FOXO4-DRI is studied as an experimental senolytic peptide. In preclinical cell models, it has been shown to compete with FOXO4 for p53 binding, promoting p53 relocation from the nucleus and activating apoptosis-associated pathways in certain senescent cells.<\/p>\n These findings are model-dependent and should not be interpreted as evidence that FOXO4-DRI targets every type of senescent cell.<\/p>\n FOXO4 es un factor de transcripci\u00f3n implicado en las respuestas al estr\u00e9s celular, la homeostasis y la regulaci\u00f3n del destino celular. En los modelos de c\u00e9lulas senescentes estudiados, FOXO4 contribuy\u00f3 a retener p53 en el n\u00facleo. FOXO4-DRI se dise\u00f1\u00f3 para interferir con esta interacci\u00f3n y liberar p53 de estos complejos nucleares.<\/p>\n En modelos murinos, la administraci\u00f3n experimental de FOXO4-DRI se asoci\u00f3 con mejoras en ciertos indicadores de homeostasis tisular, incluyendo marcadores relacionados con la funci\u00f3n renal, la densidad del pelaje y la actividad f\u00edsica. Estos resultados se obtuvieron en animales y no pueden extrapolarse directamente a humanos.<\/p>\n FOXO4-DRI uses a D-retro-inverso design in which D-amino acids are arranged in reverse sequence order. This design is commonly investigated as a method of preserving functional side-chain orientation while increasing resistance to proteolytic degradation compared with corresponding conventional L-peptides.<\/p>\n The exact stability and performance of an individual batch depend on its composition, handling and experimental conditions.<\/p>\n Some senescent cells produce a collection of inflammatory cytokines, growth factors and proteases known as the senescence-associated secretory phenotype, or SASP.<\/p>\n By investigating the selective removal of senescent cells, researchers may study whether FOXO4-DRI influences SASP-related signalling and inflammatory processes in controlled experimental models. This remains a preclinical research field and is not an established clinical application.<\/p>\n Cada lote de FOXO4-DRI se suministra con un Certificado de An\u00e1lisis. Dependiendo de la documentaci\u00f3n disponible del lote, las pruebas anal\u00edticas pueden incluir:<\/p>\n Consulte siempre el Certificado de An\u00e1lisis para conocer las especificaciones exactas y los resultados anal\u00edticos del lote suministrado.<\/p>\n FOXO4-DRI 10 mg se suministra exclusivamente para investigaci\u00f3n cient\u00edfica y de laboratorio controlada. No es un medicamento, complemento alimenticio ni producto cosm\u00e9tico, y no est\u00e1 aprobado para consumo humano, aplicaciones terap\u00e9uticas, uso cl\u00ednico ni uso veterinario.<\/p>","protected":false},"excerpt":{"rendered":" Looking to buy FOXO4-DRI for laboratory senescence research? FOXO4-DRI, short for FOXO4 D-Retro-Inverso, is a synthetic research peptide designed to interfere with the interaction between the FOXO4 transcription factor and the p53 tumour-suppressor protein.<\/p>\n This protein interaction has been investigated for its role in supporting the survival of certain senescent cells. Senescent cells have permanently stopped dividing but may remain metabolically active and release signalling molecules associated with tissue ageing and inflammatory processes.<\/p>\n In a landmark 2017 preclinical study led by researchers affiliated with Erasmus University Medical Center Rotterdam, FOXO4-DRI preferentially reduced the viability of senescent cells by disrupting FOXO4\u2013p53 binding. This promoted the relocation of active p53 and initiated apoptosis in the senescent cells studied. Control cells were less affected under the specific experimental conditions used.<\/p>\n Peptides Divas supplies FOXO4-DRI in a 10 mg format as a stable lyophilised powder. Each batch is accompanied by batch-specific analytical documentation.<\/p>\n Este producto est\u00e1 destinado exclusivamente a fines de investigaci\u00f3n de laboratorio. No est\u00e1 destinado para uso humano ni veterinario.<\/strong><\/p>","protected":false},"featured_media":741,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false,"nf_dc_page":"","om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"product_brand":[],"product_cat":[34],"product_tag":[46],"class_list":["post-740","product","type-product","status-publish","has-post-thumbnail","product_cat-recovery-repair","product_tag-10-mg","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"\nEspecificaciones del producto FOXO4-DRI<\/h2>\n
\n\n
\n \nEspecificaci\u00f3n<\/th>\n Detalles<\/th>\n<\/tr>\n<\/thead>\n \n Nombre del producto<\/td>\n FOXO4-DRI<\/td>\n<\/tr>\n \n Nombre completo<\/td>\n P\u00e9ptido FOXO4 D-Retro-Inverso<\/td>\n<\/tr>\n \n Cantidad<\/td>\n 10 mg por vial<\/td>\n<\/tr>\n \n Categor\u00eda de investigaci\u00f3n<\/td>\n Investigaci\u00f3n sobre la senescencia celular y la senolisis<\/td>\n<\/tr>\n \n Mecanismo investigado<\/td>\n Interrupci\u00f3n de la interacci\u00f3n de la prote\u00edna FOXO4\u2013p53<\/td>\n<\/tr>\n \n Pureza<\/td>\n \u226599,51 TP3T por HPLC<\/td>\n<\/tr>\n \n Forma<\/td>\n polvo liofilizado<\/td>\n<\/tr>\n \n Dise\u00f1o de p\u00e9ptidos<\/td>\n Estructura D-retro-inversa<\/td>\n<\/tr>\n \n Almacenamiento<\/td>\n Almacenar a -20 \u00b0C, protegido de la luz y la humedad.<\/td>\n<\/tr>\n \n Documentaci\u00f3n<\/td>\n Certificado de an\u00e1lisis espec\u00edfico del lote<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Relevancia de la investigaci\u00f3n cient\u00edfica<\/h2>\n
Investigaci\u00f3n sobre c\u00e9lulas senescentes<\/h3>\n
Interacci\u00f3n FOXO4\u2013p53<\/h3>\n
Investigaci\u00f3n sobre la biolog\u00eda del envejecimiento<\/h3>\n
Dise\u00f1o de p\u00e9ptido D-Retro-Inverso<\/h3>\n
Investigaci\u00f3n sobre SASP e inflamaci\u00f3n<\/h3>\n
Seguro de calidad<\/h2>\n
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Solo para uso en investigaci\u00f3n<\/h2>\n
FOXO4-DRI 10 mg \u2013 Senolytic Research Peptide<\/h1>\n