PT-141 (Bremelanotide) – Cyclic Melanocortin Research Peptide

PT-141, also known as Bremelanotide, is an advanced synthetic cyclic heptapeptide developed for professional laboratory research involving melanocortin receptor activity, central signalling pathways and cyclic peptide pharmacology. Its compact molecular structure and broad melanocortin receptor profile make PT-141 particularly relevant for studies involving MC4R and MC1R activity, G-protein-coupled receptor signalling, neuroendocrine communication and peptide structure–activity relationships. PT-141 is supplied as a premium lyophilised research material in a securely sealed vial with clear batch information, professional packaging and fast order processing from Peptides Divas.

Key Product Features

• Synthetic cyclic heptapeptide
• Also known as Bremelanotide and PT141
• Advanced melanocortin receptor agonist
• Relevant for MC4R and MC1R research
• Suitable for central melanocortin signalling studies
• Useful for GPCR pharmacology
• Relevant for cyclic peptide characterisation
• Supplied as a lyophilised research material
• Clear batch-specific product information
• Secure and discreet packaging
• Fast and trackable European delivery

What Is PT-141?

PT-141 is a synthetic melanocortin peptide with a conformationally restricted cyclic structure. The molecule belongs to the melanocortin peptide family and is structurally related to alpha-melanocyte-stimulating hormone analogues. Its cyclic design helps create a stable and clearly defined molecular profile for receptor-binding and signalling research. PT-141 is also known by its scientific name, Bremelanotide. The two names refer to the same active peptide compound.

Alternative Product Names

PT-141 may be identified under several names:

• PT-141
• PT141
• Bremelanotide
• Bremelanotide acetate
• Cyclic melanocortin peptide
• Melanocortin receptor agonist

Researchers should always confirm the exact chemical form and batch specifications using the product label and applicable analytical documentation.

Molecular Structure

Bremelanotide is a synthetic cyclic heptapeptide with an acetylated amino terminus and a free acid at the carboxyl terminus. Its peptide structure is commonly represented as: Ac-Nle-cyclo-(Asp–His–D-Phe–Arg–Trp–Lys–OH) Important structural characteristics include:

• Seven-amino-acid cyclic peptide structure
• Lactam-bridged molecular design
• Acetylated amino terminus
• Free carboxyl terminus
• Modified amino-acid components
• Conformationally restricted structure
• Broad melanocortin receptor activity
• Distinct analytical profile

These characteristics make PT-141 particularly useful for cyclic peptide, receptor-binding and structure–activity research.

Melanocortin Receptor Research

PT-141 is studied as a non-selective agonist of several melanocortin receptor subtypes. Relevant receptor systems include:

• MC1R
• MC2R
• MC3R
• MC4R
• MC5R

The relative activity of PT-141 differs between receptor subtypes, with MC1R and MC4R representing particularly important areas of scientific interest. Potential research applications include:

• Melanocortin receptor binding
• Receptor activation
• Ligand–receptor interactions
• G-protein-coupled receptor signalling
• Cyclic AMP pathways
• Intracellular signal transduction
• Receptor internalisation
• Receptor desensitisation
• Concentration–response relationships
• Comparative receptor pharmacology

MC4R and Central Signalling Research

The melanocortin 4 receptor, known as MC4R, is expressed in multiple regions of the central nervous system. This makes PT-141 particularly relevant for research involving:

• Central melanocortin signalling
• Hypothalamic receptor activity
• Neuroendocrine communication
• Neural GPCR pathways
• Behaviour-related signalling models
• Autonomic communication
• Dopamine-associated research pathways
• Receptor-expression analysis
• Central ligand–receptor interactions
• Comparative MC4R agonist studies

PT-141 is frequently used as a research reference for examining how melanocortin receptor activation may influence centrally mediated signalling.

MC1R and Melanocyte Research

MC1R is strongly associated with melanocyte biology and pigmentation-related signalling. PT-141 may therefore also be relevant for laboratory research involving:

• MC1R receptor activation
• Melanocyte signalling
• Melanin-expression pathways
• Pigmentation-related cellular models
• Receptor selectivity
• Comparative melanocortin ligands
• Cellular concentration responses
• Melanocyte gene expression
• GPCR signalling in pigment cells
• Receptor-mediated cellular communication

These applications describe laboratory research pathways and do not represent cosmetic claims.

Neuroendocrine Research

Melanocortin receptors contribute to communication between the central nervous system and endocrine pathways. Potential PT-141 research areas include:

• Neuroendocrine signalling
• Hypothalamic pathway research
• Central receptor activation
• Neural transmitter interactions
• Hormone-associated signalling
• Behavioural response models
• Autonomic nervous system research
• Receptor-mediated cellular communication
• Comparative neuropeptide pharmacology
• Central nervous system peptide research

Experimental results can differ depending on the receptor subtype, cell type, concentration, administration model and analytical method.

Cyclic Peptide Research

The conformationally restricted structure of PT-141 makes it especially relevant for peptide design and molecular engineering. Potential research topics include:

• Peptide cyclisation
• Lactam bridge formation
• Conformational restriction
• Molecular stability
• Enzymatic degradation
• Receptor-binding optimisation
• Modified amino-acid analysis
• Peptide pharmacology
• Structure–activity relationships
• Comparative linear and cyclic peptides
• Molecular modelling
• Synthetic peptide chemistry

Researchers may compare PT-141 with Melanotan II, alpha-MSH or other melanocortin ligands to examine how small structural differences influence receptor activity.

PT-141 Versus Melanotan II

PT-141 and Melanotan II are closely related cyclic melanocortin peptides, but they should not be treated as identical compounds.

Characteristic	PT-141
Scientific name	Bremelanotide
Peptide type	Cyclic heptapeptide
C-terminal structure	Free carboxylic acid
Main research profile	Central melanocortin and receptor signalling
Important receptor targets	MC4R and MC1R
Product identity	Distinct from Melanotan II

Researchers should always verify the exact compound identity before beginning laboratory analysis.

Potential Research Applications

PT-141 may be relevant for controlled scientific research involving:

• Melanocortin receptor pharmacology
• MC4R receptor signalling
• MC1R receptor activity
• Central nervous system pathways
• Neuroendocrine communication
• GPCR activation
• Cyclic AMP signalling
• Ligand–receptor interactions
• Receptor selectivity
• Receptor internalisation
• Peptide cyclisation
• Structure–activity relationships
• Comparative melanocortin research
• Analytical peptide characterisation
• Chromatographic analysis
• Mass-spectrometry analysis
• Stability and degradation testing

The exact experimental concentrations, controls and analytical procedures should be established by the qualified laboratory conducting the research.

Analytical Research

PT-141 may be suitable for professional laboratory analysis involving:

• High-performance liquid chromatography
• Liquid chromatography–mass spectrometry
• Peptide identity confirmation
• Molecular structure analysis
• Purity assessment
• Stability testing
• Degradation profiling
• Solubility assessment
• Reference-material comparison
• Receptor-binding assays
• Formulation compatibility
• Analytical method development

Product identity and analytical quality should always be evaluated using documentation associated with the applicable batch.

Product Specifications

Product characteristic	Information
Product name	PT-141
Scientific name	Bremelanotide
Alternative form	Bremelanotide acetate
Product category	Synthetic research peptide
Compound type	Cyclic melanocortin receptor agonist
Peptide structure	Cyclic heptapeptide
Important research targets	MC4R and MC1R
Primary research areas	Melanocortin and neuroendocrine signalling
Form	Lyophilised research material
Presentation	Securely sealed research vial
Documentation	Batch-specific analytical information
Packaging	Secure and discreet packaging
Intended application	Scientific, analytical and laboratory research

Lyophilised Research Format

PT-141 is supplied as a lyophilised research material in a securely sealed vial. Lyophilisation removes moisture and helps support peptide stability during controlled storage and transportation. Minor differences in physical appearance may occur due to product quantity, production conditions and residual moisture. Physical appearance alone should not be used to confirm product identity, purity or concentration. Researchers should review the applicable batch documentation before beginning laboratory analysis.

Quality and Product Transparency

Peptides Divas focuses on clear product specifications, careful handling and batch-level traceability. Available analytical information may include:

• Product identification
• Peptide structure
• Batch or lot number
• Reported purity
• HPLC analysis
• Mass-spectrometry data
• Testing information
• Product appearance
• Storage recommendations

This provides researchers with clear and traceable product information for the applicable batch.

Storage Information

Store PT-141 in its original sealed packaging under the conditions stated on the product label and applicable batch documentation. Protect the research material from:

• Direct sunlight
• Excessive heat
• Moisture
• Contamination
• Damaged packaging
• Repeated temperature fluctuations
• Unnecessary exposure to air

The receiving laboratory is responsible for establishing appropriate preparation, handling and storage procedures for its specific research protocol.

Why Choose PT-141?

PT-141 provides a distinctive cyclic molecular structure and broad melanocortin receptor research profile. Key research advantages include:

• Clearly defined cyclic heptapeptide structure
• Direct relevance to MC4R research
• Suitable for central melanocortin signalling studies
• Useful for MC1R and melanocyte research
• Relevant for GPCR pharmacology
• Valuable for cyclic peptide analysis
• Suitable for structure–activity research
• Convenient lyophilised presentation
• Clear batch-specific product information

Why Order from Peptides Divas?

Peptides Divas combines carefully selected research materials with fast, reliable and professional service. Customers benefit from:

• Clearly displayed product specifications
• Batch-specific analytical information
• Fast order processing
• Secure and discreet packaging
• Trackable shipping options
• Careful vial protection
• Responsive customer support
• Reliable European delivery

Choose PT-141 from Peptides Divas for advanced laboratory research involving melanocortin receptors, central signalling, neuroendocrine pathways and cyclic peptide pharmacology. For laboratory research use only. Not intended for human or veterinary use.