Looking to buy FOX-04 for laboratory senescence research? FOX-04, short for FOXO4 D-Retro-Inverso, is a synthetic research peptide designed to interfere with the interaction between the FOXO4 transcription factor and the p53 tumour-suppressor protein.<\/p>\n
This protein interaction has been investigated for its role in supporting the survival of certain senescent cells. Senescent cells have permanently stopped dividing but may remain metabolically active and release signalling molecules associated with tissue ageing and inflammatory processes.<\/p>\n
In a landmark 2017 preclinical study led by researchers affiliated with Erasmus University Medical Center Rotterdam, FOXO4-DRI preferentially reduced the viability of senescent cells by disrupting FOXO4\u2013p53 binding. This promoted the relocation of active p53 and initiated apoptosis in the senescent cells studied. Control cells were less affected under the specific experimental conditions used.<\/p>\n
Peptides Divas supplies FOXO4-DRI in a 10 mg format as a stable lyophilised powder. Each batch is accompanied by batch-specific analytical documentation.<\/p>\n
Este produto destina-se estritamente a fins de pesquisa laboratorial. N\u00e3o se destina ao uso humano ou veterin\u00e1rio.<\/strong><\/p>\n FOXO4-DRI is studied as an experimental senolytic peptide. In preclinical cell models, it has been shown to compete with FOXO4 for p53 binding, promoting p53 relocation from the nucleus and activating apoptosis-associated pathways in certain senescent cells.<\/p>\n These findings are model-dependent and should not be interpreted as evidence that FOXO4-DRI targets every type of senescent cell.<\/p>\n FOXO4 \u00e9 um fator de transcri\u00e7\u00e3o envolvido em respostas ao estresse celular, homeostase e regula\u00e7\u00e3o do destino celular. Nos modelos de c\u00e9lulas senescentes investigados, FOXO4 ajudou a reter p53 dentro do n\u00facleo. O FOXO4-DRI foi projetado para interferir nessa intera\u00e7\u00e3o e liberar p53 desses complexos nucleares.<\/p>\n Em modelos de camundongos, a administra\u00e7\u00e3o experimental de FOXO4-DRI foi associada a melhorias em medidas selecionadas de homeostase tecidual, incluindo marcadores relacionados \u00e0 fun\u00e7\u00e3o renal, densidade da pelagem e atividade f\u00edsica. Esses resultados foram obtidos em animais e n\u00e3o podem ser extrapolados diretamente para humanos.<\/p>\n FOXO4-DRI uses a D-retro-inverso design in which D-amino acids are arranged in reverse sequence order. This design is commonly investigated as a method of preserving functional side-chain orientation while increasing resistance to proteolytic degradation compared with corresponding conventional L-peptides.<\/p>\n The exact stability and performance of an individual batch depend on its composition, handling and experimental conditions.<\/p>\n Some senescent cells produce a collection of inflammatory cytokines, growth factors and proteases known as the senescence-associated secretory phenotype, or SASP.<\/p>\n By investigating the selective removal of senescent cells, researchers may study whether FOXO4-DRI influences SASP-related signalling and inflammatory processes in controlled experimental models. This remains a preclinical research field and is not an established clinical application.<\/p>\n Cada lote de FOXO4-DRI \u00e9 fornecido com um Certificado de An\u00e1lise. Dependendo da documenta\u00e7\u00e3o dispon\u00edvel sobre o lote, os testes anal\u00edticos podem incluir:<\/p>\n Consulte sempre o Certificado de An\u00e1lise para obter as especifica\u00e7\u00f5es exatas e os resultados anal\u00edticos do lote fornecido.<\/p>\n FOXO4-DRI 10 mg \u00e9 fornecido exclusivamente para pesquisa cient\u00edfica e laboratorial controlada. N\u00e3o \u00e9 um medicamento, suplemento alimentar ou produto cosm\u00e9tico e n\u00e3o \u00e9 aprovado para consumo humano, aplica\u00e7\u00f5es terap\u00eauticas, uso cl\u00ednico ou veterin\u00e1rio.<\/p>","protected":false},"excerpt":{"rendered":" Looking to buy FOXO4-DRI for laboratory senescence research? FOXO4-DRI, short for FOXO4 D-Retro-Inverso, is a synthetic research peptide designed to interfere with the interaction between the FOXO4 transcription factor and the p53 tumour-suppressor protein.<\/p>\n This protein interaction has been investigated for its role in supporting the survival of certain senescent cells. Senescent cells have permanently stopped dividing but may remain metabolically active and release signalling molecules associated with tissue ageing and inflammatory processes.<\/p>\n In a landmark 2017 preclinical study led by researchers affiliated with Erasmus University Medical Center Rotterdam, FOXO4-DRI preferentially reduced the viability of senescent cells by disrupting FOXO4\u2013p53 binding. This promoted the relocation of active p53 and initiated apoptosis in the senescent cells studied. Control cells were less affected under the specific experimental conditions used.<\/p>\n Peptides Divas supplies FOXO4-DRI in a 10 mg format as a stable lyophilised powder. Each batch is accompanied by batch-specific analytical documentation.<\/p>\n Este produto destina-se estritamente a fins de pesquisa laboratorial. N\u00e3o se destina ao uso humano ou veterin\u00e1rio.<\/strong><\/p>","protected":false},"featured_media":741,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false,"nf_dc_page":"","om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"product_brand":[],"product_cat":[34],"product_tag":[46],"class_list":["post-740","product","type-product","status-publish","has-post-thumbnail","product_cat-recovery-repair","product_tag-10-mg","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"\nEspecifica\u00e7\u00f5es do produto FOXO4-DRI<\/h2>\n
\n\n
\n \nEspecifica\u00e7\u00e3o<\/th>\n Detalhes<\/th>\n<\/tr>\n<\/thead>\n \n Nome do produto<\/td>\n FOXO4-DRI<\/td>\n<\/tr>\n \n Nome completo<\/td>\n Pept\u00eddeo D-Retro-Inverso FOXO4<\/td>\n<\/tr>\n \n Quantia<\/td>\n 10 mg por frasco<\/td>\n<\/tr>\n \n Categoria de pesquisa<\/td>\n Senesc\u00eancia celular e pesquisa senol\u00edtica<\/td>\n<\/tr>\n \n Mecanismo investigado<\/td>\n Interrup\u00e7\u00e3o da intera\u00e7\u00e3o proteica FOXO4\u2013p53<\/td>\n<\/tr>\n \n Pureza<\/td>\n \u226599,5% por HPLC<\/td>\n<\/tr>\n \n Forma<\/td>\n P\u00f3 liofilizado<\/td>\n<\/tr>\n \n Desenho de pept\u00eddeos<\/td>\n Estrutura D-retro-inversa<\/td>\n<\/tr>\n \n Armazenar<\/td>\n Conservar a \u221220 \u00b0C, protegido da luz e da umidade.<\/td>\n<\/tr>\n \n Documenta\u00e7\u00e3o<\/td>\n Certificado de An\u00e1lise espec\u00edfico do lote<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Relev\u00e2ncia para a pesquisa cient\u00edfica<\/h2>\n
Pesquisa sobre c\u00e9lulas senescentes<\/h3>\n
Intera\u00e7\u00e3o FOXO4\u2013p53<\/h3>\n
Pesquisa em Biologia do Envelhecimento<\/h3>\n
Design de pept\u00eddeo D-Retro-Inverso<\/h3>\n
Pesquisa sobre SASP e inflama\u00e7\u00e3o<\/h3>\n
Garantia de Qualidade<\/h2>\n
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Apenas para uso em pesquisa<\/h2>\n
FOXO4-DRI 10 mg \u2013 Senolytic Research Peptide<\/h1>\n