Looking to buy FOX-04 for laboratory senescence research? FOX-04, short for FOXO4 D-Retro-Inverso, is a synthetic research peptide designed to interfere with the interaction between the FOXO4 transcription factor and the p53 tumour-suppressor protein.<\/p>\n
This protein interaction has been investigated for its role in supporting the survival of certain senescent cells. Senescent cells have permanently stopped dividing but may remain metabolically active and release signalling molecules associated with tissue ageing and inflammatory processes.<\/p>\n
In a landmark 2017 preclinical study led by researchers affiliated with Erasmus University Medical Center Rotterdam, FOXO4-DRI preferentially reduced the viability of senescent cells by disrupting FOXO4\u2013p53 binding. This promoted the relocation of active p53 and initiated apoptosis in the senescent cells studied. Control cells were less affected under the specific experimental conditions used.<\/p>\n
Peptides Divas supplies FOXO4-DRI in a 10 mg format as a stable lyophilised powder. Each batch is accompanied by batch-specific analytical documentation.<\/p>\n
Denna produkt \u00e4r endast avsedd f\u00f6r laboratorieforsknings\u00e4ndam\u00e5l. Den \u00e4r inte avsedd f\u00f6r m\u00e4nsklig eller veterin\u00e4r anv\u00e4ndning.<\/strong><\/p>\n FOXO4-DRI is studied as an experimental senolytic peptide. In preclinical cell models, it has been shown to compete with FOXO4 for p53 binding, promoting p53 relocation from the nucleus and activating apoptosis-associated pathways in certain senescent cells.<\/p>\n These findings are model-dependent and should not be interpreted as evidence that FOXO4-DRI targets every type of senescent cell.<\/p>\n FOXO4 \u00e4r en transkriptionsfaktor involverad i cellul\u00e4ra stressreaktioner, homeostas och reglering av cellernas \u00f6de. I de unders\u00f6kta modellerna av senescenta celler hj\u00e4lpte FOXO4 till att beh\u00e5lla p53 i k\u00e4rnan. FOXO4-DRI utformades f\u00f6r att st\u00f6ra denna interaktion och frig\u00f6ra p53 fr\u00e5n dessa nukle\u00e4ra komplex.<\/p>\n I musmodeller associerades experimentell administrering av FOXO4-DRI med f\u00f6rb\u00e4ttringar i utvalda m\u00e5tt p\u00e5 v\u00e4vnadshomeostas, inklusive mark\u00f6rer relaterade till njurfunktion, p\u00e4lst\u00e4thet och fysisk aktivitet. Dessa resultat erh\u00f6lls hos djur och kan inte direkt extrapoleras till m\u00e4nniskor.<\/p>\n FOXO4-DRI uses a D-retro-inverso design in which D-amino acids are arranged in reverse sequence order. This design is commonly investigated as a method of preserving functional side-chain orientation while increasing resistance to proteolytic degradation compared with corresponding conventional L-peptides.<\/p>\n The exact stability and performance of an individual batch depend on its composition, handling and experimental conditions.<\/p>\n Some senescent cells produce a collection of inflammatory cytokines, growth factors and proteases known as the senescence-associated secretory phenotype, or SASP.<\/p>\n By investigating the selective removal of senescent cells, researchers may study whether FOXO4-DRI influences SASP-related signalling and inflammatory processes in controlled experimental models. This remains a preclinical research field and is not an established clinical application.<\/p>\n Varje FOXO4-DRI-batch levereras med ett analyscertifikat. Beroende p\u00e5 tillg\u00e4nglig batchdokumentation kan analytiska tester inkludera:<\/p>\n Se alltid analyscertifikatet f\u00f6r exakta specifikationer och analysresultat f\u00f6r den levererade batchen.<\/p>\n FOXO4-DRI 10 mg tillhandah\u00e5lls uteslutande f\u00f6r kontrollerad vetenskaplig forskning och laboratorieforskning. Det \u00e4r inte ett l\u00e4kemedel, kosttillskott eller kosmetisk produkt och \u00e4r inte godk\u00e4nt f\u00f6r m\u00e4nsklig konsumtion, terapeutiska till\u00e4mpningar, klinisk anv\u00e4ndning eller veterin\u00e4rmedicinsk anv\u00e4ndning.<\/p>","protected":false},"excerpt":{"rendered":" Looking to buy FOXO4-DRI for laboratory senescence research? FOXO4-DRI, short for FOXO4 D-Retro-Inverso, is a synthetic research peptide designed to interfere with the interaction between the FOXO4 transcription factor and the p53 tumour-suppressor protein.<\/p>\n This protein interaction has been investigated for its role in supporting the survival of certain senescent cells. Senescent cells have permanently stopped dividing but may remain metabolically active and release signalling molecules associated with tissue ageing and inflammatory processes.<\/p>\n In a landmark 2017 preclinical study led by researchers affiliated with Erasmus University Medical Center Rotterdam, FOXO4-DRI preferentially reduced the viability of senescent cells by disrupting FOXO4\u2013p53 binding. This promoted the relocation of active p53 and initiated apoptosis in the senescent cells studied. Control cells were less affected under the specific experimental conditions used.<\/p>\n Peptides Divas supplies FOXO4-DRI in a 10 mg format as a stable lyophilised powder. Each batch is accompanied by batch-specific analytical documentation.<\/p>\n Denna produkt \u00e4r endast avsedd f\u00f6r laboratorieforsknings\u00e4ndam\u00e5l. Den \u00e4r inte avsedd f\u00f6r m\u00e4nsklig eller veterin\u00e4r anv\u00e4ndning.<\/strong><\/p>","protected":false},"featured_media":741,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false,"nf_dc_page":"","om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"product_brand":[],"product_cat":[34],"product_tag":[46],"class_list":["post-740","product","type-product","status-publish","has-post-thumbnail","product_cat-recovery-repair","product_tag-10-mg","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"\nFOXO4-DRI Produktspecifikationer<\/h2>\n
\n\n
\n \nSpecifikation<\/th>\n Detaljer<\/th>\n<\/tr>\n<\/thead>\n \n Produktnamn<\/td>\n FOXO4-DRI<\/td>\n<\/tr>\n \n Fullst\u00e4ndigt namn<\/td>\n FOXO4 D-Retro-Inverso-peptid<\/td>\n<\/tr>\n \n Belopp<\/td>\n 10 mg per injektionsflaska<\/td>\n<\/tr>\n \n Forskningskategori<\/td>\n Cellul\u00e4r senescens och senolytisk forskning<\/td>\n<\/tr>\n \n Unders\u00f6kt mekanism<\/td>\n St\u00f6rning av FOXO4-p53-proteininteraktionen<\/td>\n<\/tr>\n \n Renhet<\/td>\n \u226599,5% med HPLC<\/td>\n<\/tr>\n \n Form<\/td>\n Frystorkat pulver<\/td>\n<\/tr>\n \n Peptiddesign<\/td>\n D-retro-inverso struktur<\/td>\n<\/tr>\n \n Lagring<\/td>\n F\u00f6rvaras vid \u221220 \u00b0C, skyddat fr\u00e5n ljus och fukt<\/td>\n<\/tr>\n \n Dokumentation<\/td>\n Batchspecifikt analyscertifikat<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Vetenskaplig forskningsrelevans<\/h2>\n
Forskning om \u00e5ldrande celler<\/h3>\n
FOXO4\u2013p53-interaktion<\/h3>\n
\u00c5ldrande-biologisk forskning<\/h3>\n
D-Retro-Inverso Peptide Design<\/h3>\n
SASP och inflammationsforskning<\/h3>\n
Kvalitetss\u00e4kring<\/h2>\n
\n
Endast f\u00f6r forskningsbruk<\/h2>\n
FOXO4-DRI 10 mg \u2013 Senolytic Research Peptide<\/h1>\n