TB-500 – Thymosin Beta-4 Fragment for Research

TB-500 is a synthetic research peptide corresponding to the N-acetylated 17–23 fragment of human thymosin beta-4. Its compact seven-amino-acid sequence, Ac-LKKTETQ, represents an important region associated with actin-related cellular processes. This clearly defined molecular structure makes TB-500 particularly relevant for professional laboratory studies involving actin dynamics, cytoskeletal organisation, endothelial-cell behaviour, cellular migration and peptide structure–activity relationships. TB-500 is supplied as a premium lyophilised research material in a securely sealed vial with clear batch information, professional packaging and fast order processing from Peptides Divas.

Caratteristiche principali del prodotto

• Synthetic thymosin beta-4 fragment
• N-acetylated peptide sequence
• Clearly defined Ac-LKKTETQ structure
• Seven-amino-acid research peptide
• Relevant for actin-related cellular research
• Suitable for cytoskeletal and migration studies
• Useful for endothelial-cell models
• Suitable for analytical peptide characterisation
• Fornito come materiale di ricerca liofilizzato
• Informazioni chiare sul prodotto specifiche per lotto
• Imballaggio sicuro e discreto
• Spedizione europea rapida e tracciabile.

What Is TB-500?

TB-500 is a synthetic heptapeptide identified as the N-terminally acetylated 17–23 fragment of human thymosin beta-4. Its amino-acid sequence is: Ac-Leu–Lys–Lys–Thr–Glu–Thr–Gln The abbreviated sequence is: Ac-LKKTETQ TB-500 contains the central actin-binding motif associated with thymosin beta-4, but it is a separate and much smaller research compound than full-length thymosin beta-4. This distinction is important because TB-500 and complete thymosin beta-4 have different molecular sizes, analytical profiles and research characteristics.

TB-500 Versus Thymosin Beta-4

TB-500 is often incorrectly described as being identical to thymosin beta-4. Full-length thymosin beta-4 is a naturally occurring 43-amino-acid protein involved in actin regulation. TB-500 is a synthetic seven-amino-acid fragment derived from one region of that protein.

Caratteristiche del prodotto	TB-500
Tipo composto	Synthetic peptide fragment
Sequenza peptidica	Ac-LKKTETQ
lunghezza del peptide	Seven amino acids
Parent protein	Thymosin beta-4
Parent-protein region	Amino acids 17–23
Caratteristica strutturale	N-terminal acetylation
Main research area	Actin-related cellular signalling

Researchers should confirm the exact sequence using the product label and batch-specific analytical documentation.

Actin-Related Research

Actin is an essential cellular protein involved in maintaining cell structure, movement and cytoskeletal organisation. The LKKTETQ region is associated with the actin-binding domain of thymosin beta-4, making TB-500 relevant for research involving:

• Actin-related cellular processes
• Organizzazione citoscheletrica
• Cell shape and structural dynamics
• Actin polymerisation models
• Actin-binding interactions
• Cellular movement
• Focal adhesion pathways
• Cell-to-matrix communication
• Comparative actin-binding research
• Peptide–protein interactions

The exact behaviour of the isolated TB-500 fragment may differ from the activity of complete thymosin beta-4.

Cellular Migration Research

Cellular migration is a complex process involving actin remodelling, cytoskeletal organisation, adhesion proteins and extracellular signals. TB-500 may be relevant for controlled laboratory research involving:

• migrazione cellulare
• Endothelial-cell movement
• migrazione dei fibroblasti
• Riorganizzazione del citoscheletro
• adesione cellulare
• Cell spreading
• Actin-dependent movement
• Relazioni dose-risposta
• Screening comparativo dei peptidi
• Migration-assay development

These research areas describe experimental cellular pathways and do not represent guaranteed biological or therapeutic outcomes.

Endothelial-Cell Research

Endothelial cells form the inner lining of blood vessels and are frequently used in laboratory research involving migration, adhesion and vascular signalling. Potential TB-500 research applications include:

• Endothelial-cell migration
• Endothelial-cell adhesion
• Tubule-formation models
• Cell-sprouting assays
• Vascular signalling
• Angiogenesis-associated pathways
• Organizzazione citoscheletrica
• Cell–matrix interactions
• Comparative endothelial assays
• Molecular-response analysis

Research involving thymosin beta-4 and its actin-binding region has examined endothelial migration and vessel-sprouting mechanisms in preclinical models.

Cytoskeletal Research

The cytoskeleton is a dynamic network that supports cell shape, intracellular transport, movement and division. TB-500 may be useful for studies examining:

• Actin-filament organisation
• Cytoskeletal remodelling
• Cellular polarity
• Cell-shape changes
• Intracellular transport
• migrazione cellulare
• Adhesion-complex formation
• Mechanical cellular responses
• Actin-associated protein interactions
• Comparative cytoskeletal models

Its compact sequence offers researchers a convenient way to study a specific thymosin beta-4-derived region without using the entire parent protein.

Peptide Structure Research

The small and clearly defined structure of TB-500 makes it suitable for peptide chemistry and structure–activity research. Potential research areas include:

• Synthetic heptapeptide characterisation
• N-terminal acetylation
• Stabilità dei peptidi
• Enzymatic degradation
• Peptide metabolite identification
• Relazioni struttura-attività
• Amino-acid sequence analysis
• Molecular modelling
• Peptide–protein interactions
• Comparative fragment research

Researchers may compare TB-500 with full-length thymosin beta-4, non-acetylated LKKTETQ or shorter metabolites to examine how molecular modifications affect analytical and cellular behaviour.

Metabolite Research

Analytical research has identified several shorter TB-500-related metabolites, including:

• Ac-LKKTE
• Ac-LKK
• Ac-LK
• Ac-L

These fragments may be studied in relation to:

• Peptide degradation
• Metabolic stability
• Microsomal metabolism
• Fragment identification
• Analytical detection
• Comparative peptide activity
• Mass-spectrometry method development
• Time-dependent degradation
• Reference-standard analysis

Potenziali applicazioni di ricerca

TB-500 may be relevant for controlled scientific studies involving:

• Actin-binding mechanisms
• Organizzazione citoscheletrica
• migrazione cellulare
• adesione cellulare
• modelli di cellule endoteliali
• Fibroblast models
• Vascular signalling
• Angiogenesis-associated pathways
• Peptide-fragment biology
• N-terminal acetylation
• Relazioni struttura-attività
• Stabilità dei peptidi
• Metabolite analysis
• Caratterizzazione analitica dei peptidi
• Analisi cromatografica
• Analisi mediante spettrometria di massa
• Comparative thymosin beta-4 research

Le concentrazioni esatte, i controlli e le procedure analitiche devono essere stabiliti dal laboratorio qualificato che conduce la ricerca.

Ricerca analitica

TB-500 is suitable for professional analytical applications involving:

• Cromatografia liquida ad alte prestazioni
• Cromatografia liquida-spettrometria di massa
• Conferma dell'identità del peptide
• Sequence verification
• Valutazione della purezza
• Test di stabilità
• Metabolite identification
• Profilazione del degrado
• Valutazione della solubilità
• Materiale di riferimento
• Sviluppo di metodi analitici
• Comparative peptide-fragment analysis

Because TB-500 is a short acetylated peptide, analytical procedures should be validated specifically for Ac-LKKTETQ.

Specifiche del prodotto

Caratteristiche del prodotto	Informazioni
Nome del prodotto	TB-500
Full identification	N-acetylated thymosin beta-4 fragment 17–23
Sequenza peptidica	Ac-LKKTETQ
Sequenza completa	Ac-Leu–Lys–Lys–Thr–Glu–Thr–Gln
Categoria di prodotto	Peptide sintetico per la ricerca
Tipo di peptide	N-acetylated heptapeptide
lunghezza del peptide	Seven amino acids
Parent protein	Human thymosin beta-4
Aree di ricerca principali	Actin, cytoskeletal and cellular-migration research
Modulo	Materiale di ricerca liofilizzato
Presentazione	Fiala da ricerca sigillata in modo sicuro
Documentazione	Informazioni analitiche specifiche per lotto
Confezione	Imballaggio sicuro e discreto
Applicazione prevista	Ricerca scientifica, analitica e di laboratorio

Formato di ricerca liofilizzato

TB-500 is supplied as a lyophilised research material in a securely sealed vial. Lyophilisation removes moisture and helps support peptide stability during controlled storage and transportation. Minor differences in physical appearance may occur because of quantity, production conditions and residual moisture. Product identity, sequence and analytical quality should always be confirmed using the documentation associated with the applicable batch.

Qualità e trasparenza del prodotto

Peptides Divas focuses on clear product specifications, careful handling and batch-level traceability. Available analytical information may include:

• Identificazione del prodotto
• Confirmed Ac-LKKTETQ sequence
• Numero di lotto
• Purezza dichiarata
• Analisi HPLC
• Dati di spettrometria di massa
• Informazioni sui test
• Aspetto del prodotto
• Consigli per la conservazione

This provides researchers with clear and traceable product information for the applicable batch.

Informazioni di archiviazione

Store TB-500 in its original sealed packaging according to the conditions stated on the product label and applicable batch documentation. Protect the research material from:

• Luce solare diretta
• Calore eccessivo
• Umidità
• Contaminazione
• Imballaggio danneggiato
• Fluttuazioni ripetute della temperatura
• Esposizione non necessaria all'aria

Il laboratorio ricevente è responsabile della definizione di procedure adeguate di preparazione, manipolazione e conservazione per il proprio specifico protocollo di ricerca.

Why Choose TB-500?

TB-500 provides a compact and clearly identified thymosin beta-4 fragment for advanced cellular and analytical research. Key research advantages include:

• Precisely defined Ac-LKKTETQ sequence
• Compact seven-amino-acid structure
• Relevant for actin-related research
• Suitable for cellular-migration studies
• Useful for endothelial-cell models
• Valuable for peptide-metabolite analysis
• Suitable for structure–activity research
• Comoda confezione liofilizzata
• Informazioni chiare sul prodotto specifiche per lotto

Perché ordinare da Peptides Divas?

Peptides Divas combina materiali di ricerca accuratamente selezionati con un servizio rapido, affidabile e professionale. I clienti beneficiano di:

• Specifiche del prodotto chiaramente visualizzate
• Informazioni analitiche specifiche per lotto
• Elaborazione rapida degli ordini
• Imballaggio sicuro e discreto
• Opzioni di spedizione tracciabili
• Attenta protezione della fiala
• Assistenza clienti reattiva
• Consegna affidabile in Europa

Choose TB-500 from Peptides Divas for advanced laboratory research involving actin-related signalling, cellular migration, cytoskeletal organisation and peptide-fragment analysis. For laboratory research use only. Not intended for human or veterinary use.