KPV – Melanocortin-Derived Tripeptide for Research

KPV is a compact synthetic tripeptide composed of the amino acids lysine, proline and valine. It corresponds to the C-terminal three-amino-acid sequence of alpha-melanocyte-stimulating hormone, also known as α-MSH 11–13. Its short and clearly defined molecular structure makes KPV particularly relevant for professional laboratory research involving melanocortin-derived peptide biology, epithelial-cell signalling, cytokine-associated pathways, peptide transport and short-peptide characterisation. KPV is supplied as a lyophilised research material in a securely sealed vial with clear batch-specific product information and professional packaging.

Caratteristiche principali del prodotto

• Synthetic tripeptide research material
• Composed of lysine, proline and valine
• Derived from the C-terminal region of α-MSH
• Also identified as α-MSH 11–13
• Compact and clearly defined peptide structure
• Relevant for epithelial and cytokine-signalling research
• Suitable for PepT1 transporter studies
• Useful for short-peptide characterisation
• Securely packaged research vial
• Spedizione europea rapida e tracciabile.

What Is KPV?

KPV is the three-amino-acid sequence Lys–Pro–Val. It represents the C-terminal fragment of the naturally occurring peptide hormone α-MSH. Although KPV is derived from α-MSH, it is a much smaller research peptide with its own distinctive analytical and experimental profile. Its compact structure allows researchers to examine the activity of a minimal peptide sequence separately from the complete parent hormone. KPV has been investigated primarily in preclinical research models involving epithelial cells, immune-cell signalling and inflammatory-response pathways.

Melanocortin-Derived Peptide Research

Alpha-melanocyte-stimulating hormone belongs to the melanocortin peptide family. Different regions of the α-MSH sequence are studied for their distinct receptor and signalling properties. KPV may be relevant for research examining:

• α-MSH-derived peptide fragments
• C-terminal peptide activity
• Melanocortin-associated biology
• Minimal active peptide sequences
• Peptide-fragment comparison
• Relazioni struttura-attività
• Receptor-dependent and receptor-independent signalling
• Short-peptide stability
• Cellular uptake mechanisms
• Comparative tripeptide analysis

Research indicates that the biological profile of KPV may differ from that of full-length α-MSH and may not depend exclusively on classical melanocortin-receptor activation.

Epithelial-Cell Research

KPV has attracted scientific interest in experimental models involving intestinal and skin epithelial cells. Potential laboratory research areas include:

• Epithelial-cell signalling
• Cellular barrier models
• Intestinal epithelial research
• modelli di cheratinociti
• risposte cellulari allo stress
• Cytokine-stimulated cell models
• Epithelial peptide transport
• Cell–peptide interactions
• Comparative cellular assays
• Short-peptide uptake studies

These research areas are based mainly on in-vitro and preclinical findings and should not be interpreted as established clinical effects.

PepT1 Transporter Research

PepT1 is a membrane transporter involved in the cellular uptake of dipeptides and tripeptides. Laboratory research has investigated KPV as a possible PepT1 substrate in intestinal epithelial and immune-cell models. This creates opportunities for studying how peptide size, sequence and transporter expression influence cellular uptake. Relevant research topics include:

• Peptide-transporter interactions
• PepT1-mediated cellular uptake
• Intestinal peptide transport
• Transporter-expression models
• Concentration-dependent uptake
• Cellular peptide availability
• Intracellular peptide signalling
• Comparative substrate transport
• Epithelial transport mechanisms
• Peptide-delivery research

Published studies have examined PepT1-mediated KPV uptake in cultured intestinal epithelial cells and murine intestinal models.

Cytokine and Cellular-Signalling Research

KPV is studied in experimental systems involving cytokine-stimulated cells and intracellular signalling pathways. Potential research areas include:

• Cytokine-associated signalling
• NF-κB-related laboratory models
• IL-1β-associated pathways
• Cellular-response modulation
• Immune-cell signalling
• Epithelial stress models
• Transcription-factor activity
• Signal-transduction research
• Comparative peptide activity
• Cell-based assay development

The precise molecular mechanisms associated with KPV remain an active area of research and may vary according to the cell type, transporter expression and experimental model.

Intestinal Research Models

Several preclinical studies have investigated KPV in intestinal epithelial and murine colitis models. These research environments may examine:

• Intestinal epithelial signalling
• Mucosal cell responses
• Cytokine-stimulated intestinal cells
• PepT1 transporter activity
• Cellular barrier models
• Immune–epithelial communication
• Peptide uptake in intestinal tissue
• Comparative intestinal peptide research
• Formulation and delivery strategies

These findings remain preclinical and do not establish that KPV can diagnose, prevent or treat intestinal disease in humans.

Skin and Keratinocyte Research

KPV has also been examined in experimental dermatological and keratinocyte models. Potential laboratory applications include:

• Keratinocyte signalling
• Epidermal cell models
• Ricerca sulla barriera cutanea
• Cytokine-stimulated keratinocytes
• Melanocortin-derived peptide comparison
• Percorsi di risposta cellulare
• Peptide penetration research
• Short-peptide formulation studies
• Test comparativi su cellule cutanee

Research involving cultured keratinocytes has explored whether KPV-associated signalling differs from the classical cyclic-AMP response linked to full-length α-MSH.

Short-Peptide Research

Because KPV contains only three amino acids, it is particularly useful for research involving compact peptide structures. Relevant areas include:

• Tripeptide synthesis
• Peptide-sequence analysis
• Relazioni struttura-attività
• Enzymatic stability
• Peptide degradation
• Transporter recognition
• Modificazione molecolare
• Peptide-conjugate development
• Analisi di solubilità
• Sviluppo di metodi analitici
• Comparative short-peptide research

Researchers may also compare KPV with full-length α-MSH, longer melanocortin fragments or structurally modified KPV analogues.

Applicazioni di ricerca analitica

KPV may be suitable for analytical laboratory work involving:

• Cromatografia liquida ad alte prestazioni
• Cromatografia liquida-spettrometria di massa
• Analisi dell'identità dei peptidi
• Valutazione della purezza
• Test di stabilità
• Profilazione del degrado
• Ricerca sulla solubilità
• Materiale di riferimento
• Compatibilità della formulazione
• Analytical method validation
• Short-peptide characterisation

The receiving laboratory is responsible for selecting and validating the appropriate solvents, concentrations and analytical procedures.

Specifiche del prodotto

Caratteristiche del prodotto	Informazioni
Nome del prodotto	KPV
Full sequence name	Lysine–Proline–Valine
Sequenza di amminoacidi	Lys–Pro–Val
Alternative designation	α-MSH 11–13
Categoria di prodotto	Peptide sintetico per la ricerca
Tipo di peptide	Tripeptide
lunghezza del peptide	Tre amminoacidi
Parent peptide	Alpha-melanocyte-stimulating hormone
Modulo	Materiale di ricerca liofilizzato
Presentazione	Fiala da ricerca sigillata in modo sicuro
Documentazione	Informazioni analitiche specifiche per lotto
Confezione	Imballaggio sicuro e discreto
Applicazione prevista	Ricerca scientifica, analitica e di laboratorio

Formato di ricerca liofilizzato

KPV is supplied as a lyophilised research material in a securely sealed vial. Lyophilisation removes moisture and helps support product stability during controlled storage and transportation. Minor variations in physical appearance may occur because of production conditions, quantity and residual moisture. Product identity and analytical quality should always be assessed using the applicable batch documentation rather than physical appearance alone.

Qualità e trasparenza del prodotto

Peptides Divas focuses on clear product specifications, careful handling and batch-level traceability. Available product documentation may include:

• Identificazione del prodotto
• Sequenza di amminoacidi
• Numero di lotto
• Purezza dichiarata
• Analisi HPLC
• Dati di spettrometria di massa
• Informazioni sui test
• Aspetto del prodotto
• Consigli per la conservazione

Ciò fornisce ai ricercatori informazioni chiare e tracciabili relative al lotto di prodotto in questione.

Informazioni di archiviazione

Store KPV in its original sealed packaging under the conditions stated on the product label and applicable batch documentation. Protect the research material from:

• Luce solare diretta
• Calore eccessivo
• Umidità
• Contaminazione
• Imballaggio danneggiato
• Fluttuazioni ripetute della temperatura
• Esposizione non necessaria all'aria

Il laboratorio ricevente è responsabile della definizione di procedure adeguate di preparazione, manipolazione e conservazione per il proprio specifico protocollo di ricerca.

Why Choose KPV?

KPV provides a compact and clearly defined peptide structure for advanced cellular, analytical and transporter-related research. Key research advantages include:

• Simple three-amino-acid sequence
• Clear relationship to the α-MSH peptide family
• Relevant for epithelial-cell research
• Suitable for peptide-transporter studies
• Useful for cytokine-signalling models
• Valuable for short-peptide characterisation
• Convenient lyophilised format
• Informazioni chiare sul prodotto specifiche per lotto

Perché ordinare da Peptides Divas?

Peptides Divas combines carefully selected research products with fast and professional service. Customers benefit from:

• Specifiche del prodotto chiaramente visualizzate
• Informazioni analitiche specifiche per lotto
• Elaborazione rapida degli ordini
• Imballaggio sicuro e discreto
• Opzioni di spedizione tracciabili
• Maneggiare il prodotto con cura
• Assistenza clienti reattiva
• Consegna affidabile in Europa

Choose KPV from Peptides Divas for advanced laboratory research involving melanocortin-derived peptide biology, epithelial signalling, peptide transport and short-peptide analysis. For laboratory research use only. Not intended for human or veterinary use.