Melanotan II (MT2) – Cyclic Melanocortin Research Peptide
Melanotan II, commonly known as MT2 or MT-II, is a synthetic cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone, also known as α-MSH.
Its compact cyclic structure and broad melanocortin-receptor activity make MT2 particularly relevant for advanced laboratory research involving melanocortin signalling, receptor pharmacology, pigmentation-related pathways, cellular communication and peptide structure–activity relationships.
Melanotan II is supplied as a premium lyophilised research material in a securely sealed vial with clear batch information, professional packaging and fast delivery from Peptides Divas.
Key Product Features
- Synthetic cyclic heptapeptide
- Analogue of alpha-melanocyte-stimulating hormone
- Also known as Melanotan II, MT2 and MT-II
- Broad melanocortin-receptor research profile
- Relevant for MC1R-associated pigmentation research
- Suitable for receptor-binding and signalling studies
- Useful for cyclic-peptide characterisation
- Supplied as a lyophilised research material
- Clear batch-specific product information
- Secure and discreet packaging
- Fast and trackable European delivery
What Is Melanotan II?
Melanotan II is a laboratory-designed analogue of α-MSH, a naturally occurring peptide involved in melanocortin-receptor signalling.
The molecule contains seven amino-acid components arranged in a compact cyclic structure. Cyclisation is achieved through a lactam bridge, helping create a more conformationally restricted molecule than the naturally occurring linear parent peptide.
This specialised design makes MT2 useful for researchers examining how peptide cyclisation and modified amino-acid sequences influence receptor binding, molecular stability and biological signalling.
Alternative Product Names
Melanotan II may be identified by several common research names:
- Melanotan II
- Melanotan 2
- MT2
- MT-II
- Cyclic α-MSH analogue
- Melanocortin receptor agonist
Melanotan II should not be confused with Melanotan I. The two compounds have different molecular structures and research profiles.
Molecular Structure
Melanotan II is a cyclic heptapeptide based on the active central region of α-MSH.
Important structural characteristics include:
- Seven-amino-acid peptide structure
- Cyclic lactam-bridged design
- Modified α-MSH-derived sequence
- Inclusion of non-standard amino-acid components
- Conformationally restricted molecular structure
- Broad melanocortin-receptor activity
- Distinct analytical profile compared with linear α-MSH
The cyclic design makes MT2 particularly relevant for structure–activity and peptide-engineering research.
Melanocortin-Receptor Research
Melanocortin receptors belong to the G-protein-coupled receptor family and are involved in multiple cellular and neuroendocrine signalling pathways.
Melanotan II is studied as a non-selective agonist across multiple melanocortin receptor subtypes.
Potential laboratory research areas include:
- Melanocortin-receptor binding
- Receptor activation
- Ligand–receptor interactions
- Cyclic AMP signalling
- Intracellular signal transduction
- Receptor selectivity
- Receptor internalisation
- Concentration–response relationships
- Comparative agonist pharmacology
- Structure–activity relationships
Its broad receptor profile makes MT2 useful as a reference compound in comparative melanocortin research.
MC1R and Pigmentation-Pathway Research
The melanocortin 1 receptor, commonly abbreviated as MC1R, is expressed by melanocytes and plays an important role in pigmentation biology.
MT2 may be relevant for laboratory research involving:
- MC1R receptor activation
- Melanocyte signalling
- Melanin-production pathways
- Melanogenesis
- Pigment-cell biology
- Tyrosinase-associated pathways
- Melanosome formation
- Melanosome transfer
- Cellular pigmentation responses
- Comparative α-MSH analogue research
These applications describe laboratory research pathways and do not represent cosmetic or therapeutic claims.
Melanocyte Research
Melanocytes are specialised pigment-producing cells located in the skin, hair follicles and other tissues.
Laboratory models involving MT2 may examine:
- Melanocyte receptor expression
- Cellular pigment production
- Melanin synthesis
- Cell-signalling responses
- Receptor sensitivity
- Gene-expression changes
- Pigmentation-pathway activation
- Peptide concentration responses
- Comparative melanocyte assays
- Interactions between melanocytes and keratinocytes
Research outcomes can depend on the cell type, receptor expression, concentration, exposure period and experimental method used.
Neural Melanocortin Research
Certain melanocortin receptors are expressed within the central nervous system and are studied in relation to neuroendocrine communication and energy-balance pathways.
MT2 has been used as a research tool in experimental models involving:
- Central melanocortin signalling
- MC3R- and MC4R-associated pathways
- Hypothalamic receptor activity
- Appetite-related signalling
- Satiety-related pathways
- Energy-balance models
- Autonomic communication
- Neural receptor pharmacology
- Behavioural research models
- Comparative central receptor studies
Findings from cell and animal models should not automatically be interpreted as established effects in humans.
Cyclic-Peptide Research
The cyclic structure of Melanotan II makes it particularly useful for peptide-design research.
Potential applications include:
- Peptide cyclisation
- Lactam-bridge formation
- Conformational restriction
- Enzymatic stability
- Receptor-binding optimisation
- Modified amino-acid analysis
- Structure–activity relationships
- Molecular modelling
- Peptide degradation
- Comparative linear and cyclic peptide studies
Researchers may compare MT2 with natural α-MSH, Melanotan I or other melanocortin ligands to evaluate how structural changes affect receptor activity.
Potential Research Applications
Melanotan II may be relevant for controlled scientific studies involving:
- Melanocortin receptor pharmacology
- MC1R-associated signalling
- Melanocyte biology
- Melanogenesis pathways
- Pigmentation-related cellular models
- MC3R and MC4R research
- Neuroendocrine signalling
- Energy-balance pathways
- GPCR activation
- Cyclic-peptide design
- Peptide stability
- Structure–activity relationships
- Comparative α-MSH analogue studies
- Analytical peptide characterisation
- Chromatographic analysis
- Mass-spectrometry analysis
- Stability and degradation testing
The receiving laboratory is responsible for determining and validating suitable controls, concentrations and analytical procedures.
Melanotan I Versus Melanotan II
Melanotan I and Melanotan II are related α-MSH analogues but are not identical.
| Characteristic |
Melanotan II |
| Alternative name |
MT2 or MT-II |
| Peptide type |
Cyclic heptapeptide |
| Parent peptide |
Alpha-melanocyte-stimulating hormone |
| Receptor profile |
Broad melanocortin-receptor agonist |
| Molecular design |
Lactam-bridged cyclic structure |
| Main research areas |
Receptor pharmacology and pigmentation signalling |
Always verify the exact product identity through the label and applicable batch documentation.
Product Specifications
| Product characteristic |
Information |
| Product name |
Melanotan II |
| Common abbreviation |
MT2 / MT-II |
| Product category |
Synthetic research peptide |
| Compound type |
Cyclic α-MSH analogue |
| Peptide length |
Seven amino-acid components |
| Structural feature |
Lactam-bridged cyclic structure |
| Primary research targets |
Melanocortin receptors |
| Main research areas |
Receptor and pigmentation-pathway research |
| Form |
Lyophilised research material |
| Presentation |
Securely sealed research vial |
| Documentation |
Batch-specific analytical information |
| Packaging |
Secure and discreet packaging |
| Intended application |
Scientific, analytical and laboratory research |
Lyophilised Research Format
Melanotan II is supplied as a lyophilised research material in a securely sealed vial.
Lyophilisation removes moisture and helps support peptide stability during controlled storage and transport. Minor differences in physical appearance may occur because of product quantity, manufacturing conditions and residual moisture.
Product identity, purity and analytical quality should be confirmed through the documentation associated with the applicable batch.
Quality and Product Transparency
Peptides Divas focuses on clear product information, professional handling and batch-level traceability.
Available analytical information may include:
- Product identification
- Peptide structure or sequence
- Batch or lot number
- Reported purity
- HPLC analysis
- Mass-spectrometry data
- Testing information
- Product appearance
- Storage recommendations
This provides researchers with clear and traceable information for the applicable product batch.
Storage Information
Store Melanotan II in its original sealed packaging according to the conditions displayed on the product label and applicable batch documentation.
Protect the research material from:
- Direct sunlight
- Excessive heat
- Moisture
- Contamination
- Damaged packaging
- Repeated temperature fluctuations
- Unnecessary exposure to air
The receiving laboratory is responsible for establishing suitable handling, preparation and storage procedures for its specific research protocol.
Why Choose Melanotan II?
Melanotan II offers a distinctive cyclic molecular structure and broad melanocortin-receptor research profile.
Key research advantages include:
- Clearly defined cyclic heptapeptide structure
- Direct relevance to melanocortin-receptor studies
- Suitable for MC1R-associated pathway research
- Useful for melanocyte and pigmentation models
- Valuable for cyclic-peptide analysis
- Relevant for structure–activity research
- Convenient lyophilised presentation
- Clear batch-specific product information
Why Order from Peptides Divas?
Peptides Divas combines carefully selected research materials with fast, dependable and professional service.
Customers benefit from:
- Clearly displayed product specifications
- Batch-specific analytical information
- Fast order processing
- Secure and discreet packaging
- Trackable shipping options
- Careful vial protection
- Responsive customer support
- Reliable European delivery
Choose Melanotan II from Peptides Divas for advanced laboratory research involving melanocortin receptors, pigmentation-related signalling and cyclic-peptide pharmacology.
For laboratory research use only. Not intended for human or veterinary use.
