KPV – Melanocortin-Derived Tripeptide for Research

KPV is a compact synthetic tripeptide composed of the amino acids lysine, proline and valine. It corresponds to the C-terminal three-amino-acid sequence of alpha-melanocyte-stimulating hormone, also known as α-MSH 11–13. Its short and clearly defined molecular structure makes KPV particularly relevant for professional laboratory research involving melanocortin-derived peptide biology, epithelial-cell signalling, cytokine-associated pathways, peptide transport and short-peptide characterisation. KPV is supplied as a lyophilised research material in a securely sealed vial with clear batch-specific product information and professional packaging.

Klíčové vlastnosti produktu

• Synthetic tripeptide research material
• Composed of lysine, proline and valine
• Derived from the C-terminal region of α-MSH
• Also identified as α-MSH 11–13
• Compact and clearly defined peptide structure
• Relevant for epithelial and cytokine-signalling research
• Suitable for PepT1 transporter studies
• Useful for short-peptide characterisation
• Securely packaged research vial
• Rychlé a sledovatelné doručení do Evropy

What Is KPV?

KPV is the three-amino-acid sequence Lys–Pro–Val. It represents the C-terminal fragment of the naturally occurring peptide hormone α-MSH. Although KPV is derived from α-MSH, it is a much smaller research peptide with its own distinctive analytical and experimental profile. Its compact structure allows researchers to examine the activity of a minimal peptide sequence separately from the complete parent hormone. KPV has been investigated primarily in preclinical research models involving epithelial cells, immune-cell signalling and inflammatory-response pathways.

Melanocortin-Derived Peptide Research

Alpha-melanocyte-stimulating hormone belongs to the melanocortin peptide family. Different regions of the α-MSH sequence are studied for their distinct receptor and signalling properties. KPV may be relevant for research examining:

• α-MSH-derived peptide fragments
• C-terminal peptide activity
• Melanocortin-associated biology
• Minimal active peptide sequences
• Peptide-fragment comparison
• Vztahy mezi strukturou a aktivitou
• Receptor-dependent and receptor-independent signalling
• Short-peptide stability
• Cellular uptake mechanisms
• Comparative tripeptide analysis

Research indicates that the biological profile of KPV may differ from that of full-length α-MSH and may not depend exclusively on classical melanocortin-receptor activation.

Epithelial-Cell Research

KPV has attracted scientific interest in experimental models involving intestinal and skin epithelial cells. Potential laboratory research areas include:

• Epithelial-cell signalling
• Cellular barrier models
• Intestinal epithelial research
• Modely keratinocytů
• Buněčné stresové reakce
• Cytokine-stimulated cell models
• Epithelial peptide transport
• Cell–peptide interactions
• Comparative cellular assays
• Short-peptide uptake studies

These research areas are based mainly on in-vitro and preclinical findings and should not be interpreted as established clinical effects.

PepT1 Transporter Research

PepT1 is a membrane transporter involved in the cellular uptake of dipeptides and tripeptides. Laboratory research has investigated KPV as a possible PepT1 substrate in intestinal epithelial and immune-cell models. This creates opportunities for studying how peptide size, sequence and transporter expression influence cellular uptake. Relevant research topics include:

• Peptide-transporter interactions
• PepT1-mediated cellular uptake
• Intestinal peptide transport
• Transporter-expression models
• Concentration-dependent uptake
• Cellular peptide availability
• Intracellular peptide signalling
• Comparative substrate transport
• Epithelial transport mechanisms
• Peptide-delivery research

Published studies have examined PepT1-mediated KPV uptake in cultured intestinal epithelial cells and murine intestinal models.

Cytokine and Cellular-Signalling Research

KPV is studied in experimental systems involving cytokine-stimulated cells and intracellular signalling pathways. Potential research areas include:

• Cytokine-associated signalling
• NF-κB-related laboratory models
• IL-1β-associated pathways
• Cellular-response modulation
• Immune-cell signalling
• Epithelial stress models
• Transcription-factor activity
• Signal-transduction research
• Comparative peptide activity
• Cell-based assay development

The precise molecular mechanisms associated with KPV remain an active area of research and may vary according to the cell type, transporter expression and experimental model.

Intestinal Research Models

Several preclinical studies have investigated KPV in intestinal epithelial and murine colitis models. These research environments may examine:

• Intestinal epithelial signalling
• Mucosal cell responses
• Cytokine-stimulated intestinal cells
• PepT1 transporter activity
• Cellular barrier models
• Immune–epithelial communication
• Peptide uptake in intestinal tissue
• Comparative intestinal peptide research
• Formulation and delivery strategies

These findings remain preclinical and do not establish that KPV can diagnose, prevent or treat intestinal disease in humans.

Skin and Keratinocyte Research

KPV has also been examined in experimental dermatological and keratinocyte models. Potential laboratory applications include:

• Keratinocyte signalling
• Epidermal cell models
• Výzkum kožní bariéry
• Cytokine-stimulated keratinocytes
• Melanocortin-derived peptide comparison
• Buněčné odpovědní dráhy
• Peptide penetration research
• Short-peptide formulation studies
• Srovnávací testy kožních buněk

Research involving cultured keratinocytes has explored whether KPV-associated signalling differs from the classical cyclic-AMP response linked to full-length α-MSH.

Short-Peptide Research

Because KPV contains only three amino acids, it is particularly useful for research involving compact peptide structures. Relevant areas include:

• Tripeptide synthesis
• Peptide-sequence analysis
• Vztahy mezi strukturou a aktivitou
• Enzymatic stability
• Peptide degradation
• Transporter recognition
• Molekulární modifikace
• Peptide-conjugate development
• Analýza rozpustnosti
• Vývoj analytických metod
• Comparative short-peptide research

Researchers may also compare KPV with full-length α-MSH, longer melanocortin fragments or structurally modified KPV analogues.

Aplikace analytického výzkumu

KPV may be suitable for analytical laboratory work involving:

• Vysoce výkonná kapalinová chromatografie
• Kapalinová chromatografie s hmotnostní spektrometrií
• Analýza identity peptidů
• Posouzení čistoty
• Testování stability
• Profilování degradace
• Výzkum rozpustnosti
• Porovnání referenčních materiálů
• Kompatibilita s formulací
• Analytical method validation
• Short-peptide characterisation

The receiving laboratory is responsible for selecting and validating the appropriate solvents, concentrations and analytical procedures.

Specifikace produktu

Charakteristika produktu	Informace
Název produktu	KPV
Full sequence name	Lysine–Proline–Valine
Aminokyselinová sekvence	Lys–Pro–Val
Alternative designation	α-MSH 11–13
Kategorie produktu	Syntetický výzkumný peptid
Typ peptidu	Tripeptide
Délka peptidu	Tři aminokyseliny
Parent peptide	Alpha-melanocyte-stimulating hormone
Formulář	Lyofilizovaný výzkumný materiál
Prezentace	Bezpečně uzavřená výzkumná lahvička
Dokumentace	Analytické informace specifické pro danou šarži
Obal	Bezpečné a diskrétní balení
Zamýšlené použití	Vědecký, analytický a laboratorní výzkum

Lyofilizovaný výzkumný formát

KPV is supplied as a lyophilised research material in a securely sealed vial. Lyophilisation removes moisture and helps support product stability during controlled storage and transportation. Minor variations in physical appearance may occur because of production conditions, quantity and residual moisture. Product identity and analytical quality should always be assessed using the applicable batch documentation rather than physical appearance alone.

Kvalita a transparentnost produktů

Peptides Divas focuses on clear product specifications, careful handling and batch-level traceability. Available product documentation may include:

• Identifikace produktu
• Aminokyselinová sekvence
• Číslo šarže nebo šarže
• Uváděná čistota
• HPLC analýza
• Data hmotnostní spektrometrie
• Informace o testování
• Vzhled produktu
• Doporučení pro skladování

To poskytuje výzkumníkům jasné a sledovatelné informace o příslušné šarži produktu.

Informace o úložišti

Store KPV in its original sealed packaging under the conditions stated on the product label and applicable batch documentation. Protect the research material from:

• Přímé sluneční světlo
• Nadměrné teplo
• Vlhkost
• Kontaminace
• Poškozený obal
• Opakované teplotní výkyvy
• Zbytečné vystavení vzduchu

Přijímající laboratoř je zodpovědná za stanovení vhodných postupů přípravy, manipulace a skladování pro svůj specifický výzkumný protokol.

Why Choose KPV?

KPV provides a compact and clearly defined peptide structure for advanced cellular, analytical and transporter-related research. Key research advantages include:

• Simple three-amino-acid sequence
• Clear relationship to the α-MSH peptide family
• Relevant for epithelial-cell research
• Suitable for peptide-transporter studies
• Useful for cytokine-signalling models
• Valuable for short-peptide characterisation
• Convenient lyophilised format
• Jasné informace o produktu specifické pro danou šarži

Proč objednávat od Peptides Divas?

Peptides Divas combines carefully selected research products with fast and professional service. Customers benefit from:

• Jasně zobrazené specifikace produktu
• Analytické informace specifické pro danou šarži
• Rychlé zpracování objednávky
• Bezpečné a diskrétní balení
• Možnosti sledovatelné dopravy
• Pečlivé zacházení s výrobkem
• Responzivní zákaznická podpora
• Spolehlivé evropské doručení

Choose KPV from Peptides Divas for advanced laboratory research involving melanocortin-derived peptide biology, epithelial signalling, peptide transport and short-peptide analysis. For laboratory research use only. Not intended for human or veterinary use.