TB-500 – Thymosin Beta-4 Fragment for Research

TB-500 is a synthetic research peptide corresponding to the N-acetylated 17–23 fragment of human thymosin beta-4. Its compact seven-amino-acid sequence, Ac-LKKTETQ, represents an important region associated with actin-related cellular processes. This clearly defined molecular structure makes TB-500 particularly relevant for professional laboratory studies involving actin dynamics, cytoskeletal organisation, endothelial-cell behaviour, cellular migration and peptide structure–activity relationships. TB-500 is supplied as a premium lyophilised research material in a securely sealed vial with clear batch information, professional packaging and fast order processing from Peptides Divas.

Klíčové vlastnosti produktu

• Synthetic thymosin beta-4 fragment
• N-acetylated peptide sequence
• Clearly defined Ac-LKKTETQ structure
• Seven-amino-acid research peptide
• Relevant for actin-related cellular research
• Suitable for cytoskeletal and migration studies
• Useful for endothelial-cell models
• Suitable for analytical peptide characterisation
• Dodává se jako lyofilizovaný výzkumný materiál
• Jasné informace o produktu specifické pro danou šarži
• Bezpečné a diskrétní balení
• Rychlé a sledovatelné doručení do Evropy

What Is TB-500?

TB-500 is a synthetic heptapeptide identified as the N-terminally acetylated 17–23 fragment of human thymosin beta-4. Its amino-acid sequence is: Ac-Leu–Lys–Lys–Thr–Glu–Thr–Gln The abbreviated sequence is: Ac-LKKTETQ TB-500 contains the central actin-binding motif associated with thymosin beta-4, but it is a separate and much smaller research compound than full-length thymosin beta-4. This distinction is important because TB-500 and complete thymosin beta-4 have different molecular sizes, analytical profiles and research characteristics.

TB-500 Versus Thymosin Beta-4

TB-500 is often incorrectly described as being identical to thymosin beta-4. Full-length thymosin beta-4 is a naturally occurring 43-amino-acid protein involved in actin regulation. TB-500 is a synthetic seven-amino-acid fragment derived from one region of that protein.

Charakteristika produktu	TB-500
Typ sloučeniny	Synthetic peptide fragment
Peptidová sekvence	Ac-LKKTETQ
Délka peptidu	Seven amino acids
Parent protein	Thymosin beta-4
Parent-protein region	Amino acids 17–23
Strukturální prvek	N-terminal acetylation
Main research area	Actin-related cellular signalling

Researchers should confirm the exact sequence using the product label and batch-specific analytical documentation.

Actin-Related Research

Actin is an essential cellular protein involved in maintaining cell structure, movement and cytoskeletal organisation. The LKKTETQ region is associated with the actin-binding domain of thymosin beta-4, making TB-500 relevant for research involving:

• Actin-related cellular processes
• Cytoskeletální organizace
• Cell shape and structural dynamics
• Actin polymerisation models
• Actin-binding interactions
• Cellular movement
• Focal adhesion pathways
• Cell-to-matrix communication
• Comparative actin-binding research
• Peptide–protein interactions

The exact behaviour of the isolated TB-500 fragment may differ from the activity of complete thymosin beta-4.

Cellular Migration Research

Cellular migration is a complex process involving actin remodelling, cytoskeletal organisation, adhesion proteins and extracellular signals. TB-500 may be relevant for controlled laboratory research involving:

• Buněčná migrace
• Endothelial-cell movement
• Migrace fibroblastů
• Cytoskeletální přeskupení
• Buněčná adheze
• Cell spreading
• Actin-dependent movement
• Vztahy mezi koncentrací a odezvou
• Srovnávací peptidový screening
• Migration-assay development

These research areas describe experimental cellular pathways and do not represent guaranteed biological or therapeutic outcomes.

Endothelial-Cell Research

Endothelial cells form the inner lining of blood vessels and are frequently used in laboratory research involving migration, adhesion and vascular signalling. Potential TB-500 research applications include:

• Endothelial-cell migration
• Endothelial-cell adhesion
• Tubule-formation models
• Cell-sprouting assays
• Vascular signalling
• Angiogenesis-associated pathways
• Cytoskeletální organizace
• Cell–matrix interactions
• Comparative endothelial assays
• Molecular-response analysis

Research involving thymosin beta-4 and its actin-binding region has examined endothelial migration and vessel-sprouting mechanisms in preclinical models.

Cytoskeletal Research

The cytoskeleton is a dynamic network that supports cell shape, intracellular transport, movement and division. TB-500 may be useful for studies examining:

• Actin-filament organisation
• Cytoskeletal remodelling
• Cellular polarity
• Cell-shape changes
• Intracellular transport
• Migrace buněk
• Adhesion-complex formation
• Mechanical cellular responses
• Actin-associated protein interactions
• Comparative cytoskeletal models

Its compact sequence offers researchers a convenient way to study a specific thymosin beta-4-derived region without using the entire parent protein.

Peptide Structure Research

The small and clearly defined structure of TB-500 makes it suitable for peptide chemistry and structure–activity research. Potential research areas include:

• Synthetic heptapeptide characterisation
• N-terminal acetylation
• Stabilita peptidů
• Enzymatic degradation
• Peptide metabolite identification
• Vztahy mezi strukturou a aktivitou
• Amino-acid sequence analysis
• Molecular modelling
• Peptide–protein interactions
• Comparative fragment research

Researchers may compare TB-500 with full-length thymosin beta-4, non-acetylated LKKTETQ or shorter metabolites to examine how molecular modifications affect analytical and cellular behaviour.

Metabolite Research

Analytical research has identified several shorter TB-500-related metabolites, including:

• Ac-LKKTE
• Ac-LKK
• Ac-LK
• Ac-L

These fragments may be studied in relation to:

• Peptide degradation
• Metabolic stability
• Microsomal metabolism
• Fragment identification
• Analytical detection
• Comparative peptide activity
• Mass-spectrometry method development
• Time-dependent degradation
• Reference-standard analysis

Potenciální výzkumné aplikace

TB-500 may be relevant for controlled scientific studies involving:

• Actin-binding mechanisms
• Cytoskeletální organizace
• Buněčná migrace
• Buněčná adheze
• Modely endoteliálních buněk
• Fibroblast models
• Vascular signalling
• Angiogenesis-associated pathways
• Peptide-fragment biology
• N-terminal acetylation
• Vztahy mezi strukturou a aktivitou
• Stabilita peptidů
• Metabolite analysis
• Analytická charakterizace peptidů
• Chromatografická analýza
• Analýza hmotnostní spektrometrií
• Comparative thymosin beta-4 research

Přesné koncentrace, kontroly a analytické postupy by měla stanovit kvalifikovaná laboratoř provádějící výzkum.

Analytický výzkum

TB-500 is suitable for professional analytical applications involving:

• Vysoce výkonná kapalinová chromatografie
• Kapalinová chromatografie s hmotnostní spektrometrií
• Potvrzení identity peptidu
• Sequence verification
• Posouzení čistoty
• Testování stability
• Metabolite identification
• Profilování degradace
• Posouzení rozpustnosti
• Porovnání referenčních materiálů
• Vývoj analytických metod
• Comparative peptide-fragment analysis

Because TB-500 is a short acetylated peptide, analytical procedures should be validated specifically for Ac-LKKTETQ.

Specifikace produktu

Charakteristika produktu	Informace
Název produktu	TB-500
Full identification	N-acetylated thymosin beta-4 fragment 17–23
Peptidová sekvence	Ac-LKKTETQ
Celá sekvence	Ac-Leu–Lys–Lys–Thr–Glu–Thr–Gln
Kategorie produktu	Syntetický výzkumný peptid
Typ peptidu	N-acetylated heptapeptide
Délka peptidu	Seven amino acids
Parent protein	Human thymosin beta-4
Primární oblasti výzkumu	Actin, cytoskeletal and cellular-migration research
Formulář	Lyofilizovaný výzkumný materiál
Prezentace	Bezpečně uzavřená výzkumná lahvička
Dokumentace	Analytické informace specifické pro danou šarži
Obal	Bezpečné a diskrétní balení
Zamýšlené použití	Vědecký, analytický a laboratorní výzkum

Lyofilizovaný výzkumný formát

TB-500 is supplied as a lyophilised research material in a securely sealed vial. Lyophilisation removes moisture and helps support peptide stability during controlled storage and transportation. Minor differences in physical appearance may occur because of quantity, production conditions and residual moisture. Product identity, sequence and analytical quality should always be confirmed using the documentation associated with the applicable batch.

Kvalita a transparentnost produktů

Peptides Divas focuses on clear product specifications, careful handling and batch-level traceability. Available analytical information may include:

• Identifikace produktu
• Confirmed Ac-LKKTETQ sequence
• Číslo šarže nebo šarže
• Uváděná čistota
• HPLC analýza
• Data hmotnostní spektrometrie
• Informace o testování
• Vzhled produktu
• Doporučení pro skladování

This provides researchers with clear and traceable product information for the applicable batch.

Informace o úložišti

Store TB-500 in its original sealed packaging according to the conditions stated on the product label and applicable batch documentation. Protect the research material from:

• Přímé sluneční světlo
• Nadměrné teplo
• Vlhkost
• Kontaminace
• Poškozený obal
• Opakované teplotní výkyvy
• Zbytečné vystavení vzduchu

Přijímající laboratoř je zodpovědná za stanovení vhodných postupů přípravy, manipulace a skladování pro svůj specifický výzkumný protokol.

Why Choose TB-500?

TB-500 provides a compact and clearly identified thymosin beta-4 fragment for advanced cellular and analytical research. Key research advantages include:

• Precisely defined Ac-LKKTETQ sequence
• Compact seven-amino-acid structure
• Relevant for actin-related research
• Suitable for cellular-migration studies
• Useful for endothelial-cell models
• Valuable for peptide-metabolite analysis
• Suitable for structure–activity research
• Pohodlná lyofilizovaná prezentace
• Jasné informace o produktu specifické pro danou šarži

Proč objednávat od Peptides Divas?

Peptides Divas kombinuje pečlivě vybrané výzkumné materiály s rychlým, spolehlivým a profesionálním servisem. Zákazníci těží z:

• Jasně zobrazené specifikace produktu
• Analytické informace specifické pro danou šarži
• Rychlé zpracování objednávky
• Bezpečné a diskrétní balení
• Možnosti sledovatelné dopravy
• Pečlivá ochrana lahvičky
• Responzivní zákaznická podpora
• Spolehlivé evropské doručení

Choose TB-500 from Peptides Divas for advanced laboratory research involving actin-related signalling, cellular migration, cytoskeletal organisation and peptide-fragment analysis. For laboratory research use only. Not intended for human or veterinary use.