PT-141 (Bremelanotide) – Cyclic Melanocortin Research Peptide

PT-141, also known as Bremelanotide, is an advanced synthetic cyclic heptapeptide developed for professional laboratory research involving melanocortin receptor activity, central signalling pathways and cyclic peptide pharmacology. Its compact molecular structure and broad melanocortin receptor profile make PT-141 particularly relevant for studies involving MC4R and MC1R activity, G-protein-coupled receptor signalling, neuroendocrine communication and peptide structure–activity relationships. PT-141 is supplied as a premium lyophilised research material in a securely sealed vial with clear batch information, professional packaging and fast order processing from Peptides Divas.

Caratteristiche principali del prodotto

• Synthetic cyclic heptapeptide
• Also known as Bremelanotide and PT141
• Advanced melanocortin receptor agonist
• Relevant for MC4R and MC1R research
• Suitable for central melanocortin signalling studies
• Useful for GPCR pharmacology
• Relevant for cyclic peptide characterisation
• Fornito come materiale di ricerca liofilizzato
• Informazioni chiare sul prodotto specifiche per lotto
• Imballaggio sicuro e discreto
• Spedizione europea rapida e tracciabile.

What Is PT-141?

PT-141 is a synthetic melanocortin peptide with a conformationally restricted cyclic structure. The molecule belongs to the melanocortin peptide family and is structurally related to alpha-melanocyte-stimulating hormone analogues. Its cyclic design helps create a stable and clearly defined molecular profile for receptor-binding and signalling research. PT-141 is also known by its scientific name, Bremelanotide. The two names refer to the same active peptide compound.

Alternative Product Names

PT-141 may be identified under several names:

• PT-141
• PT141
• Bremelanotide
• Bremelanotide acetate
• Cyclic melanocortin peptide
• Melanocortin receptor agonist

Researchers should always confirm the exact chemical form and batch specifications using the product label and applicable analytical documentation.

Molecular Structure

Bremelanotide is a synthetic cyclic heptapeptide with an acetylated amino terminus and a free acid at the carboxyl terminus. Its peptide structure is commonly represented as: Ac-Nle-cyclo-(Asp–His–D-Phe–Arg–Trp–Lys–OH) Important structural characteristics include:

• Seven-amino-acid cyclic peptide structure
• Lactam-bridged molecular design
• Acetylated amino terminus
• Free carboxyl terminus
• Modified amino-acid components
• Conformationally restricted structure
• Broad melanocortin receptor activity
• Distinct analytical profile

These characteristics make PT-141 particularly useful for cyclic peptide, receptor-binding and structure–activity research.

Melanocortin Receptor Research

PT-141 is studied as a non-selective agonist of several melanocortin receptor subtypes. Relevant receptor systems include:

• MC1R
• MC2R
• MC3R
• MC4R
• MC5R

The relative activity of PT-141 differs between receptor subtypes, with MC1R and MC4R representing particularly important areas of scientific interest. Potential research applications include:

• Melanocortin receptor binding
• Attivazione del recettore
• Interazioni ligando-recettore
• Segnalazione del recettore accoppiato alla proteina G
• Vie metaboliche dell'AMP ciclico
• Trasduzione del segnale intracellulare
• Internalizzazione del recettore
• Desensibilizzazione dei recettori
• Relazioni concentrazione-risposta
• Farmacologia comparata dei recettori

MC4R and Central Signalling Research

The melanocortin 4 receptor, known as MC4R, is expressed in multiple regions of the central nervous system. This makes PT-141 particularly relevant for research involving:

• Central melanocortin signalling
• Hypothalamic receptor activity
• Comunicazione neuroendocrina
• Neural GPCR pathways
• Behaviour-related signalling models
• Autonomic communication
• Dopamine-associated research pathways
• Receptor-expression analysis
• Central ligand–receptor interactions
• Comparative MC4R agonist studies

PT-141 is frequently used as a research reference for examining how melanocortin receptor activation may influence centrally mediated signalling.

MC1R and Melanocyte Research

MC1R is strongly associated with melanocyte biology and pigmentation-related signalling. PT-141 may therefore also be relevant for laboratory research involving:

• MC1R receptor activation
• Melanocyte signalling
• Melanin-expression pathways
• Pigmentation-related cellular models
• Selettività del recettore
• Comparative melanocortin ligands
• Cellular concentration responses
• Melanocyte gene expression
• GPCR signalling in pigment cells
• Receptor-mediated cellular communication

These applications describe laboratory research pathways and do not represent cosmetic claims.

Ricerca neuroendocrina

Melanocortin receptors contribute to communication between the central nervous system and endocrine pathways. Potential PT-141 research areas include:

• Segnalazione neuroendocrina
• Hypothalamic pathway research
• Central receptor activation
• Neural transmitter interactions
• Hormone-associated signalling
• Behavioural response models
• Autonomic nervous system research
• Receptor-mediated cellular communication
• Comparative neuropeptide pharmacology
• Central nervous system peptide research

Experimental results can differ depending on the receptor subtype, cell type, concentration, administration model and analytical method.

Cyclic Peptide Research

The conformationally restricted structure of PT-141 makes it especially relevant for peptide design and molecular engineering. Potential research topics include:

• Peptide cyclisation
• Lactam bridge formation
• Conformational restriction
• Stabilità molecolare
• Enzymatic degradation
• Receptor-binding optimisation
• Modified amino-acid analysis
• Farmacologia dei peptidi
• Relazioni struttura-attività
• Comparative linear and cyclic peptides
• Molecular modelling
• Synthetic peptide chemistry

Researchers may compare PT-141 with Melanotan II, alpha-MSH or other melanocortin ligands to examine how small structural differences influence receptor activity.

PT-141 Versus Melanotan II

PT-141 and Melanotan II are closely related cyclic melanocortin peptides, but they should not be treated as identical compounds.

Caratteristica	PT-141
Scientific name	Bremelanotide
Tipo di peptide	Cyclic heptapeptide
C-terminal structure	Free carboxylic acid
Main research profile	Central melanocortin and receptor signalling
Important receptor targets	MC4R and MC1R
Product identity	Distinct from Melanotan II

Researchers should always verify the exact compound identity before beginning laboratory analysis.

Potenziali applicazioni di ricerca

PT-141 may be relevant for controlled scientific research involving:

• Melanocortin receptor pharmacology
• MC4R receptor signalling
• MC1R receptor activity
• Central nervous system pathways
• Comunicazione neuroendocrina
• GPCR activation
• Segnalazione dell'AMP ciclico
• Interazioni ligando-recettore
• Selettività del recettore
• Internalizzazione del recettore
• Peptide cyclisation
• Relazioni struttura-attività
• Comparative melanocortin research
• Caratterizzazione analitica dei peptidi
• Analisi cromatografica
• Analisi mediante spettrometria di massa
• Test di stabilità e degradazione

The exact experimental concentrations, controls and analytical procedures should be established by the qualified laboratory conducting the research.

Ricerca analitica

PT-141 may be suitable for professional laboratory analysis involving:

• Cromatografia liquida ad alte prestazioni
• Cromatografia liquida-spettrometria di massa
• Conferma dell'identità del peptide
• Molecular structure analysis
• Valutazione della purezza
• Test di stabilità
• Profilazione del degrado
• Valutazione della solubilità
• Materiale di riferimento
• Receptor-binding assays
• Compatibilità della formulazione
• Sviluppo di metodi analitici

Product identity and analytical quality should always be evaluated using documentation associated with the applicable batch.

Specifiche del prodotto

Caratteristiche del prodotto	Informazioni
Nome del prodotto	PT-141
Scientific name	Bremelanotide
Alternative form	Bremelanotide acetate
Categoria di prodotto	Peptide sintetico per la ricerca
Tipo composto	Cyclic melanocortin receptor agonist
Peptide structure	Cyclic heptapeptide
Important research targets	MC4R and MC1R
Aree di ricerca principali	Melanocortin and neuroendocrine signalling
Modulo	Materiale di ricerca liofilizzato
Presentazione	Fiala da ricerca sigillata in modo sicuro
Documentazione	Informazioni analitiche specifiche per lotto
Confezione	Imballaggio sicuro e discreto
Applicazione prevista	Ricerca scientifica, analitica e di laboratorio

Formato di ricerca liofilizzato

PT-141 is supplied as a lyophilised research material in a securely sealed vial. Lyophilisation removes moisture and helps support peptide stability during controlled storage and transportation. Minor differences in physical appearance may occur due to product quantity, production conditions and residual moisture. Physical appearance alone should not be used to confirm product identity, purity or concentration. Researchers should review the applicable batch documentation before beginning laboratory analysis.

Qualità e trasparenza del prodotto

Peptides Divas focuses on clear product specifications, careful handling and batch-level traceability. Available analytical information may include:

• Identificazione del prodotto
• Peptide structure
• Numero di lotto
• Purezza dichiarata
• Analisi HPLC
• Dati di spettrometria di massa
• Informazioni sui test
• Aspetto del prodotto
• Consigli per la conservazione

This provides researchers with clear and traceable product information for the applicable batch.

Informazioni di archiviazione

Store PT-141 in its original sealed packaging under the conditions stated on the product label and applicable batch documentation. Protect the research material from:

• Luce solare diretta
• Calore eccessivo
• Umidità
• Contaminazione
• Imballaggio danneggiato
• Fluttuazioni ripetute della temperatura
• Esposizione non necessaria all'aria

Il laboratorio ricevente è responsabile della definizione di procedure adeguate di preparazione, manipolazione e conservazione per il proprio specifico protocollo di ricerca.

Why Choose PT-141?

PT-141 provides a distinctive cyclic molecular structure and broad melanocortin receptor research profile. Key research advantages include:

• Clearly defined cyclic heptapeptide structure
• Direct relevance to MC4R research
• Suitable for central melanocortin signalling studies
• Useful for MC1R and melanocyte research
• Relevant for GPCR pharmacology
• Valuable for cyclic peptide analysis
• Suitable for structure–activity research
• Comoda confezione liofilizzata
• Informazioni chiare sul prodotto specifiche per lotto

Perché ordinare da Peptides Divas?

Peptides Divas combines carefully selected research materials with fast, reliable and professional service. Customers benefit from:

• Specifiche del prodotto chiaramente visualizzate
• Informazioni analitiche specifiche per lotto
• Elaborazione rapida degli ordini
• Imballaggio sicuro e discreto
• Opzioni di spedizione tracciabili
• Attenta protezione della fiala
• Assistenza clienti reattiva
• Consegna affidabile in Europa

Choose PT-141 from Peptides Divas for advanced laboratory research involving melanocortin receptors, central signalling, neuroendocrine pathways and cyclic peptide pharmacology. For laboratory research use only. Not intended for human or veterinary use.